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CPI-360

Catalog No. T6810Cas No. 1802175-06-9
Alias Synonym 2, CPI360, CPI 360

CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.

CPI-360

CPI-360

Purity: 99.52%
Catalog No. T6810Alias Synonym 2, CPI360, CPI 360Cas No. 1802175-06-9
CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
Pack SizePriceAvailabilityQuantity
1 mg$76In Stock
5 mg$175In Stock
10 mg$285In Stock
25 mg$478In Stock
50 mg$687In Stock
100 mg$998In Stock
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Purity:99.52%
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Product Introduction

Bioactivity
Description
CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
Targets&IC50
EZH1:102.3 nM
In vitro
In KARPAS-422 cells, CPI-360 potently reduces global H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM, respectively. CPI-360 also causes time-dependent transcriptional changes, and affects the viability of Y641N mutant EZH2-containing KARPAS-422 cells. In addition, CPI-360 gradually arrests KARPAS-422 cells in the G1 cell cycle stage followed by the induction of apoptosis. [1]
In vivo
In mice bearing KARPAS-422 xenografts, CPI-360 (200 mg/kg, s.c.) reduces tumor growth by 44%. [1]
AliasSynonym 2, CPI360, CPI 360
Chemical Properties
Molecular Weight437.53
FormulaC25H31N3O4
Cas No.1802175-06-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 22.5 mg/mL (51.4 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMF: 9.0 mg/mL (20.6 mM)
Ethanol: 27.0 mg/mL (61.7 mM)
Solution Preparation Table
DMF/DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.2856 mL11.4278 mL22.8556 mL114.2779 mL
5 mM0.4571 mL2.2856 mL4.5711 mL22.8556 mL
10 mM0.2286 mL1.1428 mL2.2856 mL11.4278 mL
20 mM0.1143 mL0.5714 mL1.1428 mL5.7139 mL
DMSO/Ethanol
1mg5mg10mg50mg
50 mM0.0457 mL0.2286 mL0.4571 mL2.2856 mL

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