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CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $76 | In Stock | |
5 mg | $175 | In Stock | |
10 mg | $285 | In Stock | |
25 mg | $478 | In Stock | |
50 mg | $687 | In Stock | |
100 mg | $998 | In Stock |
Description | CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model. |
Targets&IC50 | EZH1:102.3 nM |
In vitro | In KARPAS-422 cells, CPI-360 potently reduces global H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM, respectively. CPI-360 also causes time-dependent transcriptional changes, and affects the viability of Y641N mutant EZH2-containing KARPAS-422 cells. In addition, CPI-360 gradually arrests KARPAS-422 cells in the G1 cell cycle stage followed by the induction of apoptosis. [1] |
In vivo | In mice bearing KARPAS-422 xenografts, CPI-360 (200 mg/kg, s.c.) reduces tumor growth by 44%. [1] |
Alias | Synonym 2, CPI360, CPI 360 |
Molecular Weight | 437.53 |
Formula | C25H31N3O4 |
Cas No. | 1802175-06-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (51.4 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMF: 9.0 mg/mL (20.6 mM) Ethanol: 27.0 mg/mL (61.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMF/DMSO/Ethanol
DMSO/Ethanol
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