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Cyproterone acetate

🥰Excellent
Catalog No. T1167Cas No. 427-51-0
Alias Cyproterone 17-O-acetate, Androcur

Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.

Cyproterone acetate

Cyproterone acetate

🥰Excellent
Purity: 98.43%
Catalog No. T1167Alias Cyproterone 17-O-acetate, AndrocurCas No. 427-51-0
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.
Pack SizePriceAvailabilityQuantity
100 mg$33In Stock
250 mg$54In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:98.43%
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Product Introduction

Bioactivity
Description
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.
Targets&IC50
Androgen receptor:7.1 nM
In vitro
Cyproterone acetate inhibited T-stimulated 3XHRE-LUC transcription at low concentrations in the presence of testosterone (10 nM), but not at high concentrations.Cyproterone acetate has both pronounced antagonistic and partial activator properties, and activates the AR at high relative concentrations (EC50 of 4.0 μM). In J774 macrophages
In vivo
Cyproterone acetate inhibited T-stimulated 3XHRE-LUC transcription at low concentrations in the presence of testosterone (10 nM), but not at high concentrations.Cyproterone acetate has both pronounced antagonistic and partial activator properties, and activates the AR at high relative concentrations (EC50 of 4.0 μM). In J774 macrophages
AliasCyproterone 17-O-acetate, Androcur
Chemical Properties
Molecular Weight416.94
FormulaC24H29ClO4
Cas No.427-51-0
SmilesC[C@]12[C@@]3([C@@](C3)(C(=O)C=C1C(Cl)=C[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@]5(OC(C)=O)C(C)=O)[H])[H])[H])[H])[H]
Relative Density.1.0677 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 10 mg/mL (23.98 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 40 mg/mL (95.94 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.3984 mL11.9921 mL23.9843 mL119.9213 mL
5 mM0.4797 mL2.3984 mL4.7969 mL23.9843 mL
10 mM0.2398 mL1.1992 mL2.3984 mL11.9921 mL
20 mM0.1199 mL0.5996 mL1.1992 mL5.9961 mL
DMSO
1mg5mg10mg50mg
50 mM0.0480 mL0.2398 mL0.4797 mL2.3984 mL

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