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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T40253 | 3-Phenylpropyl isothiocyanate | Others | |
3-Phenylpropyl isothiocyanate exhibits a potent inhibitory effect on N-nitrosomethyl-benzylamine (NMBA) tumorigenesis, thereby displaying strong chemopreventive properties [1] [2]. | |||
T7955 | EB-3D | Apoptosis , AMPK , AChR | |
EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor(IC50 : 1 μM).with anti-cancer activity. | |||
T9061 | EN4 | EN4 MYC inhibitor | c-Myc |
EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, an... | |||
T1167 | Cyproterone acetate | Androcur,Cyproterone 17-O-acetate | Androgen Receptor |
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ... | |||
T8350 | TPCK | Proteasome | |
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis | |||
T6322 | Copanlisib | BAY 80-6946 | Apoptosis , PI3K |
Copanlisib (BAY 80-6946) is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor c... | |||
T29669 | ADP-Ribosylarginine | alpha-ADP-ribosylarginine | |
ADP-Ribosylarginine can regulate cell proliferation and tumorigenesis. | |||
T10060L | DT-061 | Phosphatase | |
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis. | |||
T71486 | NS-0011 | ||
NS-0011 is an inhibitor of CDK5 translocation which increases CDK5 accumulation in the nucleus, suppressing both cancer cell proliferation and xenograft tumorigenesis. | |||
T9586 | Broparestrol (E)- | Others | |
Broparestrol (E)- has antifertility activity and is a potent inhibitor of rodent mammary tumorigenesis. | |||
T68755 | NZ-28 | ||
NZ28, also known as NSC134754, is potent HSF1 inhibitor, which induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Heat-shock transcript... | |||
T74602 | PROTAC EZH2 Degrader-1 | ||
PROTAC EZH2 Degrader-1 (Compound 150d), a potent inhibitor, effectively suppresses EZH2 methyltransferase activity, demonstrating an IC50 of 2.7 nM. EZH2 is crucial in various tumorigenesis and development processes [1]. | |||
T79763 | UNC9512 | DNA/RNA Synthesis | |
UNC9512 is a potent antagonist of the methyl-lysine reader protein 53BP1, which can be utilized to investigate the function of 53BP1 in DNA repair, gene editing, and tumorigenesis [1]. | |||
T62694 | (S)-GFB-12811 | ||
(S)-GFB-12811 (compound 596) is a selective and selective inhibitor of CDK5 (IC50<10 nM). (S)-GFB-12811 can be used in studies of cell cycle progression, neuronal development, and tumorigenesis. | |||
T82762 | Cdc25A (80-93) (human) | ||
Cdc25A (80-93) (human) is a polypeptide implicated in the regulation of cell proliferation and tumorigenesis through modulation of cyclin D1 expression and facilitation of the G1/S phase transition. This compound has app... | |||
T82165 | HTH-02-006 | AMPK | |
HTH-02-006, a NUAK2 inhibitor (IC50 = 126 nM), decreases phosphorylated MYPT1 levels in HuCCT-1 cells and inhibits YAP-driven cell proliferation, hepatomegaly, and tumorigenesis. Additionally, it possesses an antifibroti... | |||
T71188 | LY2780301 | ||
LY2780301 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor LY2780301 binds to and inhibits the activity of Akt, which... | |||
T76791 | Seribantumab | ||
Seribantumab (MM 121), a fully human IgG2 monoclonal antibody, specifically targets HER3, inhibiting the activation of the epidermal growth factor receptor (ErbB) family and its subsequent signaling. This action effectiv... | |||
T71267 | GNF-8625 | ||
GNE-8525 is a potent and selective pan-TRK inhibitor. GNE-8525 demonstrated potent antiproliferation activity with IC50 = 0.003 μM. In a tumor xenograft model derived from the KM12 cell line, GNE-8525 demonstrated in ... | |||
T35778 | Ochratoxin A-13C20 | Ochratoxin A-13C20 | |
Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxi... | |||
T76120 | Phospholipase D | ||
Phospholipase D (PLD), an enzyme within the phospholipase superfamily, is prevalent across bacteria, yeast, plants, animals, and viruses, serving roles in biochemical research. It catalyzes the hydrolysis of glycerophosp... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3055 | Liensinine Perchlorate | Apoptosis , Others | |
Liensinine is the active constituent of plumula nelambinis with anti-hypertension. | |||
T8017 | 2-Undecanone | Methylnonylketone | Others |
2-Undecanone (Methylnonylketone) inhibits DnaKJE-ClpB dione-dependent refolding of heat-inactivated bacterial fluorokinase. It has an inhibitory effect on lung tumorigenesis. | |||
T1051 | Retinoic acid | Vitamin A acid,ATRA,all-trans-Retinoic acid,Tretinoin | Retinoid Receptor , Endogenous Metabolite , PPAR , Autophagy |
Retinoic acid (Tretinoin), a metabolite of vitamin A, is a natural agonist of the retinoic acid receptor RAR and inhibits RARα/β/γ (IC50=14 nM). Retinoic acid induces cellular differentiation, reduces cellular proliferat... | |||
T2915 | Bardoxolone | RTA 401,CDDO | Others , Nrf2 |
Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By supp... | |||
T14317 | Ar-Turmerone | (+)-ar-Turmerone | Others |
ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-Turmerone ((+)-ar-Turmerone) exerts positive modulation on mur... | |||
TN5153 | Torilin | MMP , ERK , IκB/IKK , p38 MAPK , NF-κB , Tyrosinase , Reductase , DNA/RNA Synthesis , JNK | |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than fi... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01405 | Kallikrein 5/KLK5 Protein, Human, Recombinant (His) | Human | Human Cells |
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other di... | |||
TMPJ-00779 | TNF alpha Protein, Rabbit, Recombinant | Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor ty... | |||
TMPY-04552 | AKT1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to ... | |||
TMPY-02483 | ATP citrate lyase/ACLY Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP... | |||
TMPY-00548 | HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 |
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR... | |||
TMPY-01296 | HGFR/c-Met Protein, Human, Recombinant (His) | Human | HEK293 |
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR... | |||
TMPY-00936 | TNF alpha Protein, Human, Recombinant | Human | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-00365 | GALNT7 Protein, Human, Recombinant (His) | Human | HEK293 |
GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either ... | |||
TMPY-01744 | ACVR2A Protein, Human, Recombinant (His) | Human | HEK293 |
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately... | |||
TMPY-01447 | ACVR2A Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately... | |||
TMPY-01896 | HGFR/c-Met Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR... | |||
TMPY-01294 | TNF alpha Protein, Mouse, Recombinant | Mouse | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-04146 | TNF alpha Protein, Human, Recombinant (hFc) | Human | HEK293 |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-02202 | TNF alpha Protein, Rat, Recombinant | Rat | E. coli |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological... | |||
TMPY-05274 | IL-23R Protein, Human, Recombinant (His) | Human | HEK293 |
IL23R, also known as the IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK, and dendritic cells. Isofo... | |||
TMPY-00690 | Carbonic Anhydrase 9 Protein, Human, Recombinant (His) | Human | HEK293 |
Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzym... | |||
TMPY-00689 | Carbonic Anhydrase 9 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzym... | |||
TMPY-03523 | ANGPTL4 Protein, Human, Recombinant (His) | Human | HEK293 |
ANGPTL4, also known as ANGPTL2, is a protein with hypoxia-induced expression in endothelial cells. It contains 1 fibrinogen C-terminal domain and is expressed at high levels in the placenta, heart, liver, muscle, pancrea... | |||
TMPY-02112 | FGFR4 Protein, Human, Recombinant (His) | Human | HEK293 |
Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid seque... | |||
TMPY-00978 | Progranulin Protein, Human, Recombinant (His) | Human | HEK293 |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, ... | |||
TMPY-00021 | PADI4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase f... | |||
TMPY-03945 | Latent TGF beta 1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-04211 | Latent TGF beta 1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-00608 | TGF beta 1 Protein, Rat/Mouse, Recombinant | Mouse,Rat | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-02638 | TGF beta 1 Protein, Human/Rhesus/Cynomolgus/Canine, Recombinant | Human,Rhesus,Cynomolgus,Canine | CHO |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-01133 | Latent TGF beta 1 Protein, Human, Recombinant (His) | Human | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPY-00500 | Latent TGF beta 1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, d... | |||
TMPH-02266 | TNFAIP6 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. | |||
TMPH-02265 | TNFAIP6 Protein, Human, Recombinant (His) | Human | E. coli |
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. | |||
TMPK-00980 | EPhA2 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; t... | |||
TMPK-00742 | PRL-3/PTP4A3 Protein, Human, Recombinant (His) | Human | E. coli |
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1, PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the CNNM magnesium transport regulators. PTP4A3 (PRL-3) pla... | |||
TMPK-00979 | EPhA2 Protein, Cynomolgus, Recombinant (His & Avi) | Cynomolgus | HEK293 |
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; t... | |||
TMPY-02404 | ADAM9 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various ... | |||
TMPK-01106 | Kremen-2 Protein, Human, Recombinant (His) | Human | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPK-01304 | Kremen-2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPK-01093 | Kremen-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPY-03978 | TSPAN31 Protein, Human, Recombinant (mFc) | Human | HEK293 |
TSPAN31 is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events th... | |||
TMPH-02285 | USP6 Protein, Human, Recombinant (His & KSI) | Human | E. coli |
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activit... | |||
TMPY-00587 | GABARAP Protein, Human, Recombinant (His & MBP) | Human | E. coli |
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in... | |||
TMPK-01084 | EPhA10 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
EphA10 (erythropoietin-producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family.EphA10 was elevated and higher in tumor tissues than in ... | |||
TMPK-01083 | ASPH Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se... | |||
TMPK-00945 | ASPH Protein, Human, Recombinant (His) | Human | E. coli |
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic se... | |||
TMPJ-00854 | ETS1 Protein, Human, Recombinant (His) | Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or ... | |||
TMPK-00060 | IL-17B Protein, Mouse, Recombinant (His) | Mouse | E. coli |
IL-17A, the prototypic member of the IL-17 family, several experimental findings strongly support the role of the IL-17B/IL-17 receptor B (IL-17RB) pathway in tumorigenesis and resistance to anticancer therapies. IL-17B/... | |||
TMPK-00999 | EPhA10 Protein, Human, Recombinant (His) | Human | HEK293 |
EphA10 (erythropoietin-producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family.EphA10 was elevated and higher in tumor tissues than in ... | |||
TMPK-00061 | IGF2/IGF-II Protein, Human, Recombinant (hFc) | Human | HEK293 |
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in c... | |||
TMPJ-00475 | Kallikrein 1/KLK1 Protein, Human, Recombinant (aa 19-262, His) | Human | Human Cells |
Kallikrein-1 (KLK1) is a member of human tissue Kallikrein family. Human KLK1 precursor contains a singal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262). The f... | |||
TMPK-01327 | EPhA10 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
EphA10 (erythropoietin-producing hepatocellular carcinoma receptor A10) is a catalytically defective receptor protein tyrosine kinase in the ephrin receptor family.EphA10 was elevated and higher in tumor tissues than in ... | |||
TMPY-04271 | Frizzled 6 Protein, Human, Recombinant (His) | Human | HEK293 |
FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolated nail anomaly manifesting with onychauxis and onycholysis... | |||
TMPJ-00557 | Kallikrein 8/KLK8 Protein, Human, Recombinant (aa 29-260, His) | Human | Human Cells |
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other di... | |||
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Cat No. | Product Name | ||
---|---|---|---|
L3200 | Autophagy Compound Library | 1248 compounds | |
A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L4300 | Wnt/Hedgehog/Notch Compound Library | 240 compounds | |
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; | |||
L9000 | Apoptosis Compound Library | 1796 compounds | |
A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening; |