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Dapivirine
Catalog No. T1815Cas No. 244767-67-7
Alias TMC120, R147681
Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
Dapivirine
Catalog No. T1815Alias TMC120, R147681Cas No. 244767-67-7
Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $44 | In Stock | |
| 25 mg | $81 | In Stock | |
| 50 mg | $119 | In Stock | |
| 100 mg | $173 | In Stock | |
| 200 mg | $257 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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Purity:99.77%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. |
| Targets&IC50 | HIV RT:24 nM |
| In vivo | Dapivirine-containing gel at vaginal level inhibits cell-associated HIV infection in mice. [3] More placebo (7 of 12) than Dapivirine (3 of 24) gel users has positive vaginal swab results, with white blood cells being the most common finding. Dapivirine (0.05%) results in Cmax of 715 pg/mL, AUC of 15 ng×h/mL and T1/2 of 89.87 hours in plasma after 14 days post-dose. Mean Dapivirine (0.05%) concentrations in vaginal fluids collected at the introitus, mid vagina, and cervix are in the range of 62-265 μg/g on day 1. [4] |
| Alias | TMC120, R147681 |
| Molecular Weight | 329.4 |
| Formula | C20H19N5 |
| Cas No. | 244767-67-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 32 mg/mL (97.1 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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