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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $30 | In Stock | |
5 mg | $48 | In Stock | |
10 mg | $77 | In Stock | |
25 mg | $156 | In Stock | |
50 mg | $249 | In Stock | |
100 mg | $392 | In Stock | |
1 mL x 10 mM (in DMSO) | $62 | In Stock |
Description | Desformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48. |
Targets&IC50 | nAChR:6.48(pEC50) |
In vitro | Desformylflustrabromine hydrochloride potentiates ACh-induced responses of wild-type receptors expressed using the HS isoform preparation maximally by 350±20%, which is similar to receptors expressed via the LS isoform preparation (350±30%).[2] ACh-induced currents are potentiated and inhibited by Desformylflustrabromine hydrochloride in the high sensitivity (HS) and low sensitivity (LS) isoform preparations, although Desformylflustrabromine hydrochloride displays a higher potency on the LS isoform (pEC50=6.4±0.2) compare with the HS isoform (pEC50=5.6±0.2).[2] |
Alias | dFBr hydrochloride, Deformylflustrabromine hydrochloride |
Molecular Weight | 437.19 |
Formula | C17H12INO5 |
Cas No. | 951322-11-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 4.5 mg/mL (12.6 mM), Sonication is recommended. DMSO: 94.5 mg/mL (264.2 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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