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Dibucaine hydrochloride

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Catalog No. T0364LCas No. 61-12-1
Alias Dibucaine HCl, Cinchocaine hydrochloride, Cinchocaine HCl

Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.

Dibucaine hydrochloride

Dibucaine hydrochloride

🥰Excellent
Purity: 99.45%
Catalog No. T0364LAlias Dibucaine HCl, Cinchocaine hydrochloride, Cinchocaine HClCas No. 61-12-1
Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.
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500 mg$45In Stock
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Purity:99.45%
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Product Introduction

Bioactivity
Description
Dibucaine hydrochloride (Cinchocaine hydrochloride), a long-acting local amide anestheticsis, is usually used for surface anesthesia.
In vitro
Dibucaine (Cinchocaine) HCl is one of the most potent and toxic of the long-acting local anesthetics. [1] Dibucaine (Cinchocaine) HCl blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. [2]
AliasDibucaine HCl, Cinchocaine hydrochloride, Cinchocaine HCl
Chemical Properties
Molecular Weight379.92
FormulaC20H30ClN3O2
Cas No.61-12-1
SmilesCl.CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1
Relative Density.1.071g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 71 mg/mL (186.9 mM)
H2O: 70 mg/mL (184.2 mM)
DMSO: 60 mg/mL (157.93 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O/Ethanol
1mg5mg10mg50mg
1 mM2.6321 mL13.1607 mL26.3213 mL131.6067 mL
5 mM0.5264 mL2.6321 mL5.2643 mL26.3213 mL
10 mM0.2632 mL1.3161 mL2.6321 mL13.1607 mL
20 mM0.1316 mL0.6580 mL1.3161 mL6.5803 mL
50 mM0.0526 mL0.2632 mL0.5264 mL2.6321 mL
100 mM0.0263 mL0.1316 mL0.2632 mL1.3161 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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