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Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $33 | In Stock | |
2 mg | $46 | In Stock | |
5 mg | $72 | In Stock | |
10 mg | $117 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $328 | In Stock | |
100 mg | $487 | In Stock | |
1 mL x 10 mM (in DMSO) | $83 | In Stock |
Description | Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment. |
Targets&IC50 | Factor prolyl hydroxylase:(EC50)0.22 μM |
In vitro | Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition. |
In vivo | Enarodustat [1 and 3 mg/kg, p.o., in rats] treatment increases hemoglobin levels in a dose-dependent manner. |
Alias | JTZ-951 |
Molecular Weight | 340.33 |
Formula | C17H16N4O4 |
Cas No. | 1262132-81-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 83.33 mg/mL (244.85 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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