Estradiol cypionate (Depofemin), the 17 β-cyclopentylpropinate ester of estradiol, inhibits ET-1 synthesis via estrogen receptor.

In the field of bovine medicine, Estradiol cypionate (ECP) serves a variety of functions, including the treatment of libido deficiency due to follicular cysts, persistent corpus luteum, pyometra, and retained placenta. ECP may also aid in mitigating high-risk postpartum diseases by stimulating uterine contractions (through direct action or by maintaining oxytocin receptor sites in the uterus); enhancing uterine immune function (by increasing uterine blood flow to attract more white blood cells (WBCs) to the site of infection and augmenting the movement of IgA and IgG for bacterial phagocytosis into the uterine cavity); and promoting uterine drainage (by delaying cervical closure). Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Intramuscular administration of estradiol cypionate has been found to have the longest duration of action compared to other commonly used estradiol esters, lasting for 11 days, while estradiol benzoate and estradiol valerate have durations of 4-5 days and 7-8 days, respectively.