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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $31 | In Stock | |
2 mg | $44 | In Stock | |
5 mg | $72 | In Stock | |
10 mg | $122 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $372 | In Stock | |
100 mg | $562 | In Stock | |
200 mg | $849 | In Stock | |
1 mL x 10 mM (in DMSO) | $79 | In Stock |
Description | Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM). |
Targets&IC50 | EP4:35 nM |
In vivo | Grapiprant (0-50 mg/kg; p.o; every 24 hours; for 9 months; beagles) is safe for long-term oral administration in dogs [2]. |
Animal Research | Animal Model: 36 beagles of both sexes (9-month-old). Dosage: 0 mg/kg, 1 mg/kg, 6 mg/kg, or 50 mg/kg. Administration: Oral administration; every 24 hours; for 9 months [2] |
Alias | AAT-007, RQ-00000007, CJ-023423 |
Molecular Weight | 491.61 |
Formula | C26H29N5O3S |
Cas No. | 415903-37-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 48 mg/mL (97.64 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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