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Grapiprant

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Purity:99.49%

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COA HNMR HPLC

Grapiprant

Catalog No. TQ0292Cas No. 415903-37-6

Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM).

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Pack Size	Price	Availability
1 mg	$31	In Stock
2 mg	$44	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$197	In Stock
50 mg	$372	In Stock
100 mg	$562	In Stock
200 mg	$849	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Product Introduction

Bioactivity

Description	Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM).
Targets&IC50	EP4:35 nM
In vivo	Grapiprant (0-50 mg/kg; p.o; every 24 hours; for 9 months; beagles) is safe for long-term oral administration in dogs [2].
Animal Research	Animal Model: 36 beagles of both sexes (9-month-old). Dosage: 0 mg/kg, 1 mg/kg, 6 mg/kg, or 50 mg/kg. Administration: Oral administration; every 24 hours; for 9 months [2]
Alias	AAT-007, RQ-00000007, CJ-023423

Chemical Properties

Molecular Weight	491.61
Formula	C26H29N5O3S
Cas No.	415903-37-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 48 mg/mL (97.64 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0341 mL	10.1707 mL	20.3413 mL	101.7066 mL
5 mM	0.4068 mL	2.0341 mL	4.0683 mL	20.3413 mL
10 mM	0.2034 mL	1.0171 mL	2.0341 mL	10.1707 mL
20 mM	0.1017 mL	0.5085 mL	1.0171 mL	5.0853 mL
50 mM	0.0407 mL	0.2034 mL	0.4068 mL	2.0341 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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