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HLCL-61 hydrochloride

HLCL-61 hydrochloride
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Purity:99.91%
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HLCL-61 hydrochloride

Catalog No. T6857Cas No. 1158279-20-9
HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$72In Stock
25 mg$122In Stock
50 mg$197In Stock
100 mg$372In Stock
200 mg$521In Stock
500 mg$846In Stock
1 mL x 10 mM (in DMSO)$52In Stock
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Product Introduction

Bioactivity
Description
HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
Targets&IC50
PRMT5:16.74 μM
In vitro
HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h[1].
Cell Research
CD11b expression is tested by flow cytometry on cells treated with DMSO or HLCL-61 (25 and 50 μM) for 48 h.(Only for Reference)
AliasHLCL61, HLCL-61 HCL
Chemical Properties
Molecular Weight380.91
FormulaC23H24N2O·ClH
Cas No.1158279-20-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (131.26 mM), Heating is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 15 mg/mL (32.7 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.6253 mL13.1265 mL26.2529 mL131.2646 mL
5 mM0.5251 mL2.6253 mL5.2506 mL26.2529 mL
10 mM0.2625 mL1.3126 mL2.6253 mL13.1265 mL
20 mM0.1313 mL0.6563 mL1.3126 mL6.5632 mL
DMSO
1mg5mg10mg50mg
50 mM0.0525 mL0.2625 mL0.5251 mL2.6253 mL
100 mM0.0263 mL0.1313 mL0.2625 mL1.3126 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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