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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $47 | In Stock | |
10 mg | $72 | In Stock | |
25 mg | $122 | In Stock | |
50 mg | $197 | In Stock | |
100 mg | $372 | In Stock | |
200 mg | $521 | In Stock | |
500 mg | $846 | In Stock | |
1 mL x 10 mM (in DMSO) | $52 | In Stock |
Description | HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia. |
Targets&IC50 | PRMT5:16.74 μM |
In vitro | HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h[1]. |
Cell Research | CD11b expression is tested by flow cytometry on cells treated with DMSO or HLCL-61 (25 and 50 μM) for 48 h.(Only for Reference) |
Alias | HLCL61, HLCL-61 HCL |
Molecular Weight | 380.91 |
Formula | C23H24N2O·ClH |
Cas No. | 1158279-20-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (131.26 mM), Heating is recommended. ![]() H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 15 mg/mL (32.7 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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