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INH6

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Purity:99.17%

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COA HNMR HPLC

INH6

Catalog No. T6180Cas No. 1001753-24-7

INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.

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Pack Size	Price	Availability
10 mg	$42	In Stock
25 mg	$91	In Stock
50 mg	$148	In Stock
100 mg	$279	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Product Introduction

Bioactivity

Description	INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
In vitro	INH6 effectively targets the Hec1/Nek2 complex for degradation, and shows potent cell killing activity with IC50 of 1.7, 2.1, 2.4, and 2.5 μM in MDA-MB231, MDA-MB468, HeLa and K562 cell lines. INH6 also triggers mitotic abnormalities in HeLa cells, and induces apoptosis. [1]
Cell Research	Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH analogs in cultured cells. Triplicate sets are measured and compiled for final data presentation. The assay is performed by using a commercial kit following the instructions. In principle, cells are plated on 96-well dishes one day before the drug treatment, followed by drug treatment on day 2 and XTT assay on day 5 after drug addition. The absorption at 595 nm is measured with a plate reader and converted to cell survival percentages in comparison to mock treated groups.(Only for Reference)

Chemical Properties

Molecular Weight	322.42
Formula	C19H18N2OS
Cas No.	1001753-24-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (186.1 mM)

Ethanol: 9 mg/mL (27.9 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.1015 mL	15.5077 mL	31.0154 mL	155.0772 mL
5 mM	0.6203 mL	3.1015 mL	6.2031 mL	31.0154 mL
10 mM	0.3102 mL	1.5508 mL	3.1015 mL	15.5077 mL
20 mM	0.1551 mL	0.7754 mL	1.5508 mL	7.7539 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0620 mL	0.3102 mL	0.6203 mL	3.1015 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5508 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc