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IPI-9119

IPI-9119 is an orally active, selective, and irreversible FASN inhibitor (IC50 = 0.3 nM).

Catalog No. T36841Cas No. 1346564-56-4

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Purity:98.86%

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COA HNMR HPLC

IPI-9119

Catalog No. T36841Cas No. 1346564-56-4

IPI-9119 is an orally active, selective, and irreversible FASN inhibitor (IC50 = 0.3 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$163	In Stock
5 mg	$413	In Stock
10 mg	$596	In Stock
25 mg	$953	In Stock
50 mg	$1,320	In Stock
100 mg	$1,790	In Stock
1 mL x 10 mM (in DMSO)	$448	In Stock

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Product Introduction

Bioactivity

Description	IPI-9119 is an orally active, selective, and irreversible FASN inhibitor (IC50 = 0.3 nM).
Targets&IC50	FASN:0.3 nM (IC50)
In vitro	IPI-9119 (0.05, 0.1, 0.25, 0.5, 5 μM; 6 days) inhibits AR-FL and AR-V7 protein expression. IPI-9119 (0.1, 0.5 μM; 6 days) inhibits cell growth and induces cell cycle arrest and apoptosis[1]. IPI-9119 inhibits FASN in cellular occupancy assays (IC50∼10nM) and shows more than 400-fold selectivity against several additional serine hydrolases[2].
In vivo	IPI-9119 inhibits tumor growth of castration-resistant prostate cancer in xenografts mouse models[1].

Chemical Properties

Molecular Weight	495.43
Formula	C₂₄H₁₉F₂N₅O₅
Cas No.	1346564-56-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 95 mg/mL (191.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0184 mL	10.0922 mL	20.1845 mL	100.9224 mL
5 mM	0.4037 mL	2.0184 mL	4.0369 mL	20.1845 mL
10 mM	0.2018 mL	1.0092 mL	2.0184 mL	10.0922 mL
20 mM	0.1009 mL	0.5046 mL	1.0092 mL	5.0461 mL
50 mM	0.0404 mL	0.2018 mL	0.4037 mL	2.0184 mL
100 mM	0.0202 mL	0.1009 mL	0.2018 mL	1.0092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc