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IPI-9119

IPI-9119
IPI-9119 is an orally active, selective, and irreversible FASN inhibitor (IC50 = 0.3 nM).
Catalog No. T36841Cas No. 1346564-56-4
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Purity:98.86%
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IPI-9119

Catalog No. T36841Cas No. 1346564-56-4
IPI-9119 is an orally active, selective, and irreversible FASN inhibitor (IC50 = 0.3 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$163In Stock
5 mg$413In Stock
10 mg$596In Stock
25 mg$953In Stock
50 mg$1,320In Stock
100 mg$1,790In Stock
1 mL x 10 mM (in DMSO)$448In Stock
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Product Introduction

Bioactivity
Description
IPI-9119 is an orally active, selective, and irreversible FASN inhibitor (IC50 = 0.3 nM).
Targets&IC50
FASN:0.3 nM (IC50)
In vitro
IPI-9119 (0.05, 0.1, 0.25, 0.5, 5 μM; 6 days) inhibits AR-FL and AR-V7 protein expression. IPI-9119 (0.1, 0.5 μM; 6 days) inhibits cell growth and induces cell cycle arrest and apoptosis[1]. IPI-9119 inhibits FASN in cellular occupancy assays (IC50∼10nM) and shows more than 400-fold selectivity against several additional serine hydrolases[2].
In vivo
IPI-9119 inhibits tumor growth of castration-resistant prostate cancer in xenografts mouse models[1].
Chemical Properties
Molecular Weight495.43
FormulaC24H19F2N5O5
Cas No.1346564-56-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 95 mg/mL (191.75 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0184 mL10.0922 mL20.1845 mL100.9224 mL
5 mM0.4037 mL2.0184 mL4.0369 mL20.1845 mL
10 mM0.2018 mL1.0092 mL2.0184 mL10.0922 mL
20 mM0.1009 mL0.5046 mL1.0092 mL5.0461 mL
50 mM0.0404 mL0.2018 mL0.4037 mL2.0184 mL
100 mM0.0202 mL0.1009 mL0.2018 mL1.0092 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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