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IPI-9119 is an orally active, selective, and irreversible FASN inhibitor (IC50 = 0.3 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | In Stock | |
5 mg | $248 | In Stock | |
10 mg | $358 | In Stock | |
25 mg | $572 | In Stock | |
50 mg | $792 | In Stock | |
100 mg | $1,070 | In Stock | |
200 mg | $1,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $269 | In Stock |
Description | IPI-9119 is an orally active, selective, and irreversible FASN inhibitor (IC50 = 0.3 nM). |
Targets&IC50 | FASN:0.3 nM (IC50) |
In vitro | IPI-9119 (0.05, 0.1, 0.25, 0.5, 5 μM; 6 days) inhibits AR-FL and AR-V7 protein expression. IPI-9119 (0.1, 0.5 μM; 6 days) inhibits cell growth and induces cell cycle arrest and apoptosis[1]. IPI-9119 inhibits FASN in cellular occupancy assays (IC50∼10nM) and shows more than 400-fold selectivity against several additional serine hydrolases[2]. |
In vivo | IPI-9119 inhibits tumor growth of castration-resistant prostate cancer in xenografts mouse models[1]. |
Molecular Weight | 495.43 |
Formula | C24H19F2N5O5 |
Cas No. | 1346564-56-4 |
Smiles | CC(C)N(C(=O)n1nnn(-c2c(F)cccc2F)c1=O)c1ccc(cc1Oc1ccccc1)C(O)=O |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 95 mg/mL (191.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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