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ISX-9

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Purity:99.47%

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COA HNMR HPLC

ISX-9

Catalog No. T2003Cas No. 832115-62-5

ISX-9 (Isoxazole 9) is essential for activating neuron-specific genes and serves as a neurogenesis inducer.

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Pack Size	Price	Availability
2 mg	$41	In Stock
5 mg	$66	In Stock
10 mg	$98	In Stock
25 mg	$157	In Stock
50 mg	$222	In Stock
100 mg	$397	In Stock
500 mg	$936	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock

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Product Introduction

Bioactivity

Description	ISX-9 (Isoxazole 9) is essential for activating neuron-specific genes and serves as a neurogenesis inducer.
In vitro	In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1]
In vivo	In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2]
Cell Research	Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference)
Alias	Isoxazole 9, Isoxazole 9 (ISX-9)

Chemical Properties

Molecular Weight	234.27
Formula	C11H10N2O2S
Cas No.	832115-62-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 11 mg/mL (47 mM)

DMSO: 40 mg/mL (170.74 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2686 mL	21.3429 mL	42.6858 mL	213.4289 mL
5 mM	0.8537 mL	4.2686 mL	8.5372 mL	42.6858 mL
10 mM	0.4269 mL	2.1343 mL	4.2686 mL	21.3429 mL
20 mM	0.2134 mL	1.0671 mL	2.1343 mL	10.6714 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0854 mL	0.4269 mL	0.8537 mL	4.2686 mL
100 mM	0.0427 mL	0.2134 mL	0.4269 mL	2.1343 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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