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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $57 | In Stock | |
2 mg | $82 | In Stock | |
5 mg | $139 | In Stock | |
10 mg | $222 | In Stock | |
25 mg | $447 | In Stock | |
50 mg | $659 | In Stock | |
100 mg | $939 | In Stock | |
500 mg | $1,880 | In Stock | |
1 mL x 10 mM (in DMSO) | $155 | In Stock |
Description | JNJ-38877618 (OMO-1) is an effective and highly selective inhibitor of Met kinase (IC50s: 2 and 3 nM for wild type and mutant Met, respectively). |
Targets&IC50 | MET (mutant):2 nM, MET (WT):2 nM |
In vitro | JNJ-38877618 shows nM potency against Met Ampl/mutant and therapy-resistant models. JNJ-38877618 has nM binding affinity (Kd=1.4 nM) and enzyme inhibitory activity against wt and M1268T mutant Met (2 and 3 nM IC50). Met inhibitory effects are assessed in proliferation, colony formation, and motility assays. |
In vivo | JNJ-38877618 effectively induces regression in substantial Met-amplified EBC-1 SqNSCLC by dose- and time-dependently inhibiting Met kinase activation, with the inhibition lasting significantly longer than its plasma presence. It entirely halts tumor growth in three distinct models: SNU5 Met amp gastric, U87-MG HGF autocrine glioblastoma, and Hs746T Met exon 14 skipping mutant gastric cancer. Additionally, combination therapies are well tolerated and enhance EGFR-targeted treatments[1]. |
Alias | OMO-1 |
Molecular Weight | 374.35 |
Formula | C20H12F2N6 |
Cas No. | 943540-74-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.5 mg/mL (12.02 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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