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K-Ras(G12C) inhibitor 12

Catalog No. T6555Cas No. 1469337-95-8

K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of the oncogenic K-Ras(G12C) protein.

K-Ras(G12C) inhibitor 12

K-Ras(G12C) inhibitor 12

Purity: 97.16%
Catalog No. T6555Cas No. 1469337-95-8
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of the oncogenic K-Ras(G12C) protein.
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
5 mg$96In Stock
10 mg$145In Stock
25 mg$263In Stock
50 mg$396In Stock
100 mg$596In Stock
1 mL x 10 mM (in DMSO)$105In Stock
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Purity:97.16%
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Product Introduction

Bioactivity
Description
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of the oncogenic K-Ras(G12C) protein.
In vitro
K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines. [1]
Chemical Properties
Molecular Weight449.67
FormulaC15H17ClIN3O3
Cas No.1469337-95-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 26 mg/mL (57.8 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2239 mL11.1193 mL22.2385 mL111.1927 mL
5 mM0.4448 mL2.2239 mL4.4477 mL22.2385 mL
10 mM0.2224 mL1.1119 mL2.2239 mL11.1193 mL
20 mM0.1112 mL0.5560 mL1.1119 mL5.5596 mL
50 mM0.0445 mL0.2224 mL0.4448 mL2.2239 mL

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