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LMP744 hydrochloride
LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
Catalog No. T11872LCas No. 308246-57-3
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Purity:98.44%
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LMP744 hydrochloride
Catalog No. T11872LAlias NSC706744 hydrochloride, MJ-III65 hydrochlorideCas No. 308246-57-3
LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $122 | In Stock | |
| 5 mg | $239 | In Stock | |
| 10 mg | $372 | In Stock | |
| 25 mg | $623 | In Stock | |
| 50 mg | $888 | In Stock | |
| 100 mg | $1,220 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. |
| In vitro | LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].The GI50 value of LMP744 for NCI60 cells is 0.1 μM[2]. |
| In vivo | LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[1]. |
| Alias | NSC706744 hydrochloride, MJ-III65 hydrochloride |
| Molecular Weight | 488.92 |
| Formula | C24H25ClN2O7 |
| Cas No. | 308246-57-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.56 mg/mL (11.37 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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