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LY2562175

🥰Excellent
Catalog No. T15806Cas No. 1103500-20-4

LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).

LY2562175

LY2562175

🥰Excellent
Purity: 99.78%
Catalog No. T15806Cas No. 1103500-20-4
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
Pack SizePriceAvailabilityQuantity
1 mg$106In Stock
5 mg$239In Stock
10 mg$388In Stock
25 mg$778In Stock
50 mg$1,230In Stock
100 mg$1,650In Stock
200 mg$2,230In Stock
1 mL x 10 mM (in DMSO)$283In Stock
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Purity:99.78%
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Product Introduction

Bioactivity
Description
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
Targets&IC50
FXR:(EC50)193 nM
In vitro
LY2562175 boosts transcriptional activation of human FXR in a cell-based co-transfection assay (EC50: 193 nM) and it also promotes the recruitment of a peptide from the nuclear receptor interaction domain of the coactivator SRC-1 (a relative EC50: 121 nM). It has 93.5% efficacy as compare to GW4064.
In vivo
LY2562175 induces a dose-dependent decrease in serum cholesterol and serum triglycerides. LY2562175(female ZDF rats) treatment, causes a dose-dependent lowering of plasma triglycerides in the fasted and nonfasted states. LY2562175 further lowers fasted and nonfasted plasma triglycerides when administered as a fixed-dose combination with BRL49653. At a dose of 10 mg/kg, the decrease in cholesterol with LY2562175 is 80% below vehicle-treated animals, and the decrease in serum triglycerides is 76% from the control group. The ED50 for serum cholesterol is determined to be 2 and 3.4 mg/kg for serum triglycerides. FPLC fractionation of the lipoproteins shows that LY2562175 treatment causes a reduction in vLDL-C and a dramatic increase in HDL-c in this animal model.
Chemical Properties
Molecular Weight540.44
FormulaC28H27Cl2N3O4
Cas No.1103500-20-4
SmilesCn1cc(C(O)=O)c2ccc(cc12)N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 0.1 mg/mL (insoluble)
DMSO: 62.5 mg/mL (115.65 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8503 mL9.2517 mL18.5034 mL92.5172 mL
5 mM0.3701 mL1.8503 mL3.7007 mL18.5034 mL
10 mM0.1850 mL0.9252 mL1.8503 mL9.2517 mL
20 mM0.0925 mL0.4626 mL0.9252 mL4.6259 mL
50 mM0.0370 mL0.1850 mL0.3701 mL1.8503 mL
100 mM0.0185 mL0.0925 mL0.1850 mL0.9252 mL

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