Shopping Cart

Remove All

Your shopping cart is currently empty

Nilvadipine

Select Batch

Purity:99.78%

Resource Download

COA HNMR LCMS HPLC

Nilvadipine

Catalog No. T1422Cas No. 75530-68-6

Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
10 mg	$46	In Stock
50 mg	$61	In Stock
100 mg	$97	In Stock
200 mg	$136	In Stock
500 mg	$361	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Nilvadipine"

Product Introduction

Bioactivity

Description	Nilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.
In vitro	In RCS rats' retinas, Nilvadipine significantly increased the expression of rhodopsin kinase and αA-crystallin, while it decreased the expression of caspase-1 and caspase-2. It also entirely inhibited arterial vasoactivity induced by Abeta in rat aortas and human brains. Furthermore, Nilvadipine (0.4 mg/kg i.v. and 2 mg/kg p.o.) was able to reduce paw edema induced by localized ischemia in mice.
In vivo	In perfused hydronephrotic kidneys, Nilvadipine effectively dilates both afferent and efferent arterioles, enhancing renal blood flow. Moreover, in rat aortic smooth muscle cells (IC50=0.1 nM), Nilvadipine inhibits the chemotactic responses to interleukin-1, leukotriene B4, and platelet-derived growth factor.
Alias	FK235, FR34235, ARC029

Chemical Properties

Molecular Weight	385.37
Formula	C19H19N3O6
Cas No.	75530-68-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 19.3 mg/mL (50 mM)

DMSO: 55 mg/mL (142.72 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.5949 mL	12.9745 mL	25.9491 mL	129.7454 mL
5 mM	0.5190 mL	2.5949 mL	5.1898 mL	25.9491 mL
10 mM	0.2595 mL	1.2975 mL	2.5949 mL	12.9745 mL
20 mM	0.1297 mL	0.6487 mL	1.2975 mL	6.4873 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0519 mL	0.2595 mL	0.5190 mL	2.5949 mL
100 mM	0.0259 mL	0.1297 mL	0.2595 mL	1.2975 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc