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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $45 | In Stock | |
2 mg | $64 | In Stock | |
5 mg | $97 | In Stock | |
10 mg | $167 | In Stock | |
25 mg | $282 | In Stock | |
50 mg | $418 | In Stock | |
100 mg | $618 | In Stock | |
1 mL x 10 mM (in DMSO) | $137 | In Stock |
Description | Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein. |
Targets&IC50 | MDM2-p53 interaction:90 nM |
Kinase Assay | Biacore studies: Competition assays are performed on a Biacore S51. A Series S Sensor chip CM5 is derivatized for immobilization of a PentaHis antibody for capture of the His-tagged p53. The level of capture is ~ 200 response units (1 response unit corresponds to 1 pg of protein per mm 2). The concentration of MDM2 protein is kept constant at 300 nM. Test compounds are dissolved in DMSO at 10 mM and further diluted to make a concentration series of inhibitor in each MDM2 test sample. The assays are run at 25 °C in running buffer (10 mM Hepes, 0.15 M NaCl, 2% DMSO). MDM2-p53 binding in the presence of inhibitor is calculated as a percentage of binding in the absence of inhibitor and IC50 is calculated using Microsoft Excel |
Cell Research | SRB(Only for Reference) |
Alias | (-)-Nutlin-3, Nutlin-3a chiral, (−)-Nutlin-3 |
Molecular Weight | 581.49 |
Formula | C30H30Cl2N4O4 |
Cas No. | 675576-98-4 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 58.2 mg/mL (100 mM) DMSO: 55 mg/mL (94.58 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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