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Perifosine
🥰Excellent
Catalog No. T2492Cas No. 157716-52-4
Alias NSC 639966, KRX-0401, D21266
Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.
Perifosine
🥰Excellent
Purity: 100%
Catalog No. T2492Alias NSC 639966, KRX-0401, D21266Cas No. 157716-52-4
Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $39 | In Stock | |
| 5 mg | $63 | In Stock | |
| 10 mg | $81 | In Stock | |
| 25 mg | $163 | In Stock | |
| 50 mg | $297 | In Stock | |
| 100 mg | $468 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity. |
| Targets&IC50 | Akt:4.7 μM |
| In vitro | In MM.1S cells, Perifosine (10 μM) completely inhibited Akt phosphorylation. In immortalized keratinocytes and head and neck squamous carcinoma cells (IC50=0.6-8.9 μM), Perifosine inhibited cell proliferation. In mouse glial progenitor cells, Perifosine induced cell cycle arrest at G1 and G2 by reducing the phosphorylation level of Akt and extracellular signal-regulated kinases, causing cell growth inhibition. In human hepatocellular carcinoma cells, Perifosine induced cell cycle arrest and apoptosis by blocking Akt phosphorylation. |
| In vivo | In MM.1S cells, Perifosine (10 μM) completely inhibited Akt phosphorylation. In immortalized keratinocytes and head and neck squamous carcinoma cells (IC50=0.6-8.9 μM), Perifosine inhibited cell proliferation. In mouse glial progenitor cells, Perifosine induced cell cycle arrest at G1 and G2 by reducing the phosphorylation level of Akt and extracellular signal-regulated kinases, causing cell growth inhibition. In human hepatocellular carcinoma cells, Perifosine induced cell cycle arrest and apoptosis by blocking Akt phosphorylation. |
| Kinase Assay | Akt kinase assay: MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit. |
| Cell Research | Cells are incubated in the medium with 10% FCS for 48 hours with indicated concentration of Periosine. Cell viability is determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (Cell Proliferation Kit I; Roche). The absorbance at 590 nm is recorded using the 96-well plate reader.(Only for Reference) |
| Alias | NSC 639966, KRX-0401, D21266 |
| Molecular Weight | 461.66 |
| Formula | C25H52NO4P |
| Cas No. | 157716-52-4 |
| Smiles | O(P(OCCCCCCCCCCCCCCCCCC)(=O)[O-])C1CC[N+](C)(C)CC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: Insoluble H2O: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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