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Phenylephrine

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Purity:99.92%

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COA HNMR HPLC

Phenylephrine

Catalog No. T17310Cas No. 59-42-7

Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

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Pack Size	Price	Availability	Quantity
500 mg	$42	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Product Introduction

Bioactivity

Description	Phenylephrine ((R)-(-)-Phenylephrine) is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).
Targets&IC50	α1B-adrenoceptor:4.87 (pKi), α1D-adrenoceptor:5.86 (pKi), α1A-adrenoceptor:4.70 (pKi)
In vitro	Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis [1][2][3].
In vivo	Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes [4][5].
Alias	L-Phenylephrine, (R)-(-)-Phenylephrine

Chemical Properties

Molecular Weight	167.21
Formula	C9H13NO2
Cas No.	59-42-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (598.05 mM), Sonication is recommended.

H2O: 5 mg/mL (29.90 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.9805 mL	29.9025 mL	59.8050 mL	299.0252 mL
5 mM	1.1961 mL	5.9805 mL	11.9610 mL	59.8050 mL
10 mM	0.5981 mL	2.9903 mL	5.9805 mL	29.9025 mL
20 mM	0.2990 mL	1.4951 mL	2.9903 mL	14.9513 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.1196 mL	0.5981 mL	1.1961 mL	5.9805 mL
100 mM	0.0598 mL	0.2990 mL	0.5981 mL	2.9903 mL

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