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Pinostrobin
🥰Excellent
Catalog No. TN2082Cas No. 480-37-5
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα2(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis.
Pinostrobin
🥰Excellent
Purity: 99.35%
Catalog No. TN2082Cas No. 480-37-5
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα2(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $56 | In Stock | |
| 5 mg | $147 | In Stock | |
| 10 mg | $239 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $137 | In Stock |
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Purity:99.35%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of ce |
| In vitro | Pinostrobin was isolated from the dichloromethane extract of Renealmia alpinia leaves. The protective properties of the extract and of Pinostrobin against the indirect hemolytic, coagulant and proteolytic effects of Bothrops asper venom were evaluated in vitro, and the anti-hemorrhagic and anti-inflammatory activity were evaluated in vivo. Renealmia alpinia extract significantly inhibited the proteolytic activity and indirect hemolytic activity of Bothrops asper venom at a venom:extract ratio of 1:20. Moreover, the present data demonstrate that Pinostrobin may mitigate some venom-induced local tissue damage due to hemorrhagic effects, and the compound is also responsible for the analgesic and anti-inflammatory activity of the extract from Renealmia alpinia. This is the first report to describe Pinostrobin in the species Renealmia alpinia and its properties in vitro against Bothrops asper venom[1] |
| Molecular Weight | 270.28 |
| Formula | C16H14O4 |
| Cas No. | 480-37-5 |
| Smiles | COc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccccc1 |
| Relative Density. | 1.284 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (221.98 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
βAmyloidβ AmyloidTNF-αthreoninkinaseThreonine proteasesthreonin kinaseSerinekinaseSerine proteasesSerine kinaseSerine endopeptidasesSer/Thr ProteasePinostrobinPCSK9InhibitorinhibitILReceptorIL ReceptorfoxO3acholesterolBetaAmyloidBeta AmyloidbAmyloidb Amyloidanti-oxidantanti-inflammatoryanti-cancer,neuroprotective
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