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PKG drug G1

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Purity:97.57%

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COA LCMS HNMR

PKG drug G1

Catalog No. T4661Cas No. 374703-78-3

PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.

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Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$51	In Stock
10 mg	$79	In Stock
25 mg	$158	In Stock
50 mg	$239	In Stock
100 mg	$363	In Stock
500 mg	$855	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock

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Product Introduction

Bioactivity

Description	PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
In vivo	The absorption rate following oral administration is 80% in rats and >90% in dogs and monkeys. The metabolism of Asimadoline is rapid and appears similar in animals and man. Asimadoline has peripheral anti-inflammatory actions that are partly mediated through increase in joint fluid substance P levels
Animal Research	Mice constitutively expressing PKG Iα Cys42Ser are generated on a pure C57BL/6 background. Age-matched and. body weight–matched WT or PKG Iα Cys42Ser KI male mice are used in all studies. Blood pressure and heart rate are. assessed by radio telemetry in conscious freely moving mice. Alzet osmotic mini-pumps are used to deliver. angiotensin II at 1.1 mg/kg per day in some studies. PKG drug G1 is delivered intraperitoneally (3.7-14.8 mg/kg) or. orally (20 mg/kg) in some studies. To deliver PKG drug G1 orally, without stress or risk of dislodging the telemetric. probe catheter, it is provided suspended in water and set in gelatin flavored with sodium saccharin.

Chemical Properties

Molecular Weight	257.31
Formula	C13H11N3OS
Cas No.	374703-78-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (64.77 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8864 mL	19.4318 mL	38.8636 mL	194.3181 mL
5 mM	0.7773 mL	3.8864 mL	7.7727 mL	38.8636 mL
10 mM	0.3886 mL	1.9432 mL	3.8864 mL	19.4318 mL
20 mM	0.1943 mL	0.9716 mL	1.9432 mL	9.7159 mL
50 mM	0.0777 mL	0.3886 mL	0.7773 mL	3.8864 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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