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Prinomastat

Prinomastat
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Purity:99.23%
ee:98.178%

Prinomastat

Catalog No. T12539LCas No. 192329-42-3
Prinomastat (AG3340) is an orally active and selective inhibitor of metalloproteinases (MMPs) that crosses the blood-brain barrier.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$75In Stock
5 mg$315In Stock
10 mg$593In Stock
25 mg$1,200In Stock
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Product Introduction

Bioactivity
Description
Prinomastat (AG3340) is an orally active and selective inhibitor of metalloproteinases (MMPs) that crosses the blood-brain barrier.
In vitro
In C57MG/Wnt1 cells, Prinomastat (0.1 µg/mL, 1 µg/mL; 4 days) significantly decreases MMP-3 promoter activity[1].
In vivo
In a human fibrosarcoma mouse model (HT1080), Prinomastat (50 mg/kg; intraperitoneal injection) is well tolerated by the animals, and exhibits significant tumor growth inhibition. It has a short half-life of 1.6 hours.
AliasKB-R9896, AG3340
Chemical Properties
Molecular Weight423.51
FormulaC18H21N3O5S2
Cas No.192329-42-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 1 mg/mL (2.36 mM)
H2O: 1 mg/mL (2.36 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
5 mM0.4722 mL2.3612 mL4.7224 mL23.6122 mL
10 mM0.2361 mL1.1806 mL2.3612 mL11.8061 mL
20 mM0.1181 mL0.5903 mL1.1806 mL5.9030 mL
50 mM0.0472 mL0.2361 mL0.4722 mL2.3612 mL
100 mM0.0236 mL0.1181 mL0.2361 mL1.1806 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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