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Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 mg | 123 € | In Stock | |
50 mg | 188 € | In Stock | |
1 mL x 10 mM (in DMSO) | 133 € | In Stock |
Description | Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and ch |
In vitro | METHODS: Human cervical cells ME-180 were treated with Punicalagin (10-100 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: Punicalagin showed significant concentration-dependent cytotoxicity against ME-180 cells. The cell viability of Punicalagin-treated cells was reduced by approximately 80% compared to control cells. [1] METHODS: Human cervical cancer cells, the HeLa, were treated with Punicalagin (25-100 µM) for 36 h. The cell cycle was detected by Flow cytometry. RESULTS: The number of G1-phase cells increased significantly after 36 h of Punicalagin treatment. [2] |
In vivo | METHODS: To study the effects on MTX-induced hepatotoxicity in mice, Punicalagin (25-50 mg/kg, 0.5% CMC) was administered orally to Swiss albino mice once daily for ten days, followed by a single dose of MTX (20 mg/kg) injected intraperitoneally on the seventh day. RESULTS: Punicalagin significantly attenuated MTX-induced elevation of serum aminotransferases, ALP, and LDH, as well as hepatic oxidative stress measures, and enhanced hepatic antioxidant defense. In MTX-induced mouse liver, Punicalagin inhibited oxidative damage, inflammation and apoptosis and upregulated Nrf2. [3] |
Molecular Weight | 1084.72 |
Formula | C48H28O30 |
Cas No. | 65995-63-3 |
Smiles | O=C1C=2C=3C=4C5=C(C=6C(=CC(O)=C(O)C6O)C(=O)OCC(O)C(OC(=O)C=7C(C2C(O)=C(O)C3OC5=O)=C(O)C(O)=C(O)C7)C8C(C=O)OC(=O)C=9C(C=%10C(C(=O)O8)=CC(O)=C(O)C%10O)=C(O)C(O)=C(O)C9)C(O)=C(O)C4O1 |
Relative Density. | 2.076 g/cm3 (Predicted) |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (50.7 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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