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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $122 | In Stock | |
5 mg | $268 | In Stock | |
10 mg | $428 | In Stock | |
25 mg | $688 | In Stock | |
50 mg | $969 | In Stock | |
100 mg | $1,230 | In Stock | |
1 mL x 10 mM (in DMSO) | $362 | In Stock |
Description | Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template. |
In vitro | Quarfloxin effectively inhibits the growth of neuroblastoma cells in vitro. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1]. |
Alias | CX-3543 |
Molecular Weight | 604.67 |
Formula | C35H33FN6O3 |
Cas No. | 865311-47-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/ml (90.96 mM) ![]() H2O: 1 mg/mL (1.65 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
DMSO
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