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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $51 | In Stock | |
5 mg | $113 | In Stock | |
10 mg | $166 | In Stock | |
25 mg | $279 | In Stock | |
50 mg | $419 | In Stock | |
1 mL x 10 mM (in DMSO) | $127 | In Stock |
Description | Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2. |
Targets&IC50 | PLA2:2.6 μM |
In vitro | In the HepG2, rapanone (20–40 μM) induced a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization.Rapanone impairs mitochondrial respiration by inhibiting electron transport chain at Complex III and promotes mitochondrial dysfunction[1]. |
In vivo | In mice,rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model |
Alias | 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone, 2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione |
Molecular Weight | 322.44 |
Formula | C19H30O4 |
Cas No. | 573-40-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 65 mg/ml (201.59 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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