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Rilapladib

🥰Excellent
Catalog No. T16751Cas No. 412950-08-4
Alias SB 659032

Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2, IC50 = 230 pM) and acts as an antagonist of the platelet-activating factor receptor.

Rilapladib

Rilapladib

🥰Excellent
Purity: 97.29%
Catalog No. T16751Alias SB 659032Cas No. 412950-08-4
Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2, IC50 = 230 pM) and acts as an antagonist of the platelet-activating factor receptor.
Pack SizePriceAvailabilityQuantity
1 mg89 €In Stock
5 mg227 €In Stock
10 mg369 €In Stock
25 mg622 €In Stock
50 mg885 €In Stock
100 mg1.206 €In Stock
1 mL x 10 mM (in DMSO)368 €In Stock
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Purity:97.29%
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Product Introduction

Bioactivity
Description
Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2, IC50 = 230 pM) and acts as an antagonist of the platelet-activating factor receptor.
Targets&IC50
Lp-PLA2:230 pM
In vitro
Rilapladib reduces the PAF biological activity and levels, thereby reducing Lp-PLA2 biosynthesis and preventing the possible adverse effects of Lp-PLA2 [2].
AliasSB 659032
Chemical Properties
Molecular Weight735.8
FormulaC40H38F5N3O3S
Cas No.412950-08-4
SmilesCOCCN1CCC(CC1)N(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c(SCc2cccc(F)c2F)cc(=O)c2ccccc12
Relative Density.1.36g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 78 mg/mL (106 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3591 mL6.7953 mL13.5906 mL67.9532 mL
5 mM0.2718 mL1.3591 mL2.7181 mL13.5906 mL
10 mM0.1359 mL0.6795 mL1.3591 mL6.7953 mL
20 mM0.0680 mL0.3398 mL0.6795 mL3.3977 mL
50 mM0.0272 mL0.1359 mL0.2718 mL1.3591 mL
100 mM0.0136 mL0.0680 mL0.1359 mL0.6795 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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