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Rivanicline 2HCl
Catalog No. T12738L1
Alias Rivanicline 2HCl(15585-43-0 Free base)
Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.
Rivanicline 2HCl
Catalog No. T12738L1Alias Rivanicline 2HCl(15585-43-0 Free base)
Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $68 | In Stock | |
| 10 mg | $107 | In Stock | |
| 25 mg | $259 | In Stock | |
| 50 mg | $467 | In Stock | |
| 100 mg | $685 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $118 | In Stock |
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Purity:99.76%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype. |
| In vitro | The study investigates the impact of selectively inhibiting Akt in proliferating cells that express Trop-2. In cells expressing Trop-2, Akt inhibition, whether achieved through silencing or specific drugs, significantly reduces cell proliferation in a dose-dependent manner.[1] |
| In vivo | When Trop-2-expressing tumors are subcutaneously injected into animal models, they exhibit a remarkable reduction in growth upon treatment with specific drugs targeting Akt activity. This underscores the central functional role of Akt in mediating the Trop-2-dependent growth stimulus.[1] |
| Alias | Rivanicline 2HCl(15585-43-0 Free base) |
| Molecular Weight | 235.15 |
| Formula | C10H16Cl2N2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (212.63 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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