Tyrphostin A9 (SF 6847) is an Agricultural acaricide, now superseded. Tyrphostin A9 is firstly designed as an EGFR inhibitor

PDGFR:0.5 μM, EGFR:460 μM

SF 6847 prevents the PDGF-induced tyrosine phosphorylation of LGF in caveolae of human fibroblasts, suggesting that PDGF-BB-mediated activation of LRP requires tyrosine phosphorylation and thereby activates PDGFR-β. Additionally, SF 6847 inhibits the replication of Herpes Simplex Virus Type 1 (HSV-1) with an IC50 of 40 nM and enhances the inclusion of MAPT exon 10 in SHSY-5Y cells by twofold at a concentration of 1.6 μM. At 1 mM, it blocks the strain-induced stimulation of DNA synthesis in fetal lung cells. SF 6847 partially reverses vanadate-induced HSV-1 plaque formation at 50 nM and reduces viral phosphoprotein phosphorylation in a dose-dependent manner at concentrations below 400 nM. However, the reduction in protein synthesis induced by SF 6847 at concentrations below 800 nM is not dose-dependent.