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YH239-EE

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Purity:99.61%

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COA HPLC LCMS HNMR

YH239-EE

Catalog No. T6149Cas No. 1364488-67-4

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

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Pack Size	Price	Availability
5 mg	$60	In Stock
10 mg	$96	In Stock
25 mg	$198	In Stock
50 mg	$369	In Stock
100 mg	$549	In Stock
1 mL x 10 mM (in DMSO)	$100	In Stock

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Product Introduction

Bioactivity

Description	YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
In vitro	YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). [1]
Cell Research	Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.(Only for Reference)

Chemical Properties

Molecular Weight	504.41
Formula	C25H27Cl2N3O4
Cas No.	1364488-67-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 15 mg/mL (29.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (184.4 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.9825 mL	9.9126 mL	19.8251 mL	99.1257 mL
5 mM	0.3965 mL	1.9825 mL	3.9650 mL	19.8251 mL
10 mM	0.1983 mL	0.9913 mL	1.9825 mL	9.9126 mL
20 mM	0.0991 mL	0.4956 mL	0.9913 mL	4.9563 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0397 mL	0.1983 mL	0.3965 mL	1.9825 mL
100 mM	0.0198 mL	0.0991 mL	0.1983 mL	0.9913 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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