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YM-58790
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YM-58790
Catalog No. T72038Cas No. 168830-70-4
YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder contraction in rats by inhibiting bladder pressurization. YM-58790 free base inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $147 | In Stock | |
| 5 mg | $323 | In Stock | |
| 10 mg | $516 | In Stock | |
| 25 mg | $990 | In Stock | |
| 50 mg | $1,680 | In Stock | |
| 100 mg | $2,698 | In Stock | |
| 500 mg | $3,780 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | YM-58790 free base is a potent mAChR antagonist.YM-58790 free base inhibited M1 mAChR, M2 mAChR, and M3 mAChR with Ki values of 28 nM, 260 nM, and 15 nM, respectively.YM-58790 free base inhibits reflex rhythmic bladder contraction in rats by inhibiting bladder pressurization. YM-58790 free base inhibits reflex rhythmic bladder contractions in rats by inhibiting bladder pressurization. |
| In vitro | YM-58790 free base (compound 18b) (0-1 μM) exerts a potent inhibitory effect on urinary bladder contraction while having minimal impact on bradycardia. In vitro, YM-58790 demonstrates selective antagonism between urinary bladder contraction and salivary secretion.[1] |
| In vivo | YM-58790 free base (3 mg/kg, i.v.) exhibits no impact on oxotremorine-induced tremor in mice.[1] YM-58790 free base (6.0 mg/kg; i.v.) exhibits limited M1 and M2 antagonistic effects in vivo on McN-A343-induced pressor response in pithed rats. However, it demonstrates robust efficacy in M3 antagonism, with an ED30 value of 0.36 mg/kg and an ID50 value of 2.4 mg/kg.[1] YM-58790 free base demonstrates robust inhibitory activity on bladder pressure during reflexly-evoked rhythmic contractions in rats.[1] |
| Alias | YM-58790 free base |
| Molecular Weight | 429.55 |
| Formula | C27H31N3O2 |
| Cas No. | 168830-70-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (139.68 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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