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YQ128

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Purity:99.67%

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COA HNMR HPLC

YQ128

Catalog No. T13375Cas No. 2454246-18-3

YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.

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Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$322	In Stock
50 mg	$538	In Stock
100 mg	$777	In Stock
1 mL x 10 mM (in DMSO)	$147	In Stock

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Product Introduction

Bioactivity

Description	YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
In vitro	The release of IL-1β from peritoneal macrophages upon LPS/ATP challenge(IC50 of 1.59 μM) dose dependently suppressed by YQ128 (0.3-100 μM; 30 mins).
In vivo	YQ128 (oral; 20 mg/kg) shows delayed gastrointestinal absorption with a tmax and cmax of 12 h and 73 ng/mL, respectively. YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vdss) of 8.5 L/kg and rapid total clearance (CLtot) of 41 mL/min/kg. In C57BL/6 mice, YQ128 (10 mg/kg) has been shown to trigger IL-1β production in a NLRP3- dependent manner .

Chemical Properties

Molecular Weight	545.11
Formula	C27H29ClN2O4S2
Cas No.	2454246-18-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 248 mg/mL (454.95 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8345 mL	9.1725 mL	18.3449 mL	91.7246 mL
5 mM	0.3669 mL	1.8345 mL	3.6690 mL	18.3449 mL
10 mM	0.1834 mL	0.9172 mL	1.8345 mL	9.1725 mL
20 mM	0.0917 mL	0.4586 mL	0.9172 mL	4.5862 mL
50 mM	0.0367 mL	0.1834 mL	0.3669 mL	1.8345 mL
100 mM	0.0183 mL	0.0917 mL	0.1834 mL	0.9172 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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