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ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | 29 € | In Stock | |
10 mg | 48 € | In Stock | |
25 mg | 87 € | In Stock | |
50 mg | 169 € | In Stock | |
100 mg | 273 € | In Stock | |
200 mg | 411 € | In Stock | |
500 mg | 653 € | In Stock | |
1 mL x 10 mM (in DMSO) | 32 € | In Stock |
Description | ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α. |
In vitro | ZLN005 (15 mg/kg, p.o.) exhibits anti-hyperglycemic and anti-hyperlipidemic effects, and enhances insulin sensitivity in db/db mice without effecting lean mice. |
In vivo | In L6 myotubes, ZLN005 enhances glucose uptake and fatty acid oxidation by activating AMP-activated protein kinase (AMPK), and it elevates the expression of PGC-1α genes and downstream genes without significant toxicity. However, the same effects are not observed in primary rat hepatocytes, indicating cell-specific actions. |
Molecular Weight | 250.34 |
Formula | C17H18N2 |
Cas No. | 49671-76-3 |
Smiles | CC(C)(C)c1ccc(cc1)-c1nc2ccccc2[nH]1 |
Relative Density. | 1.102 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 2 mg/mL (7.98 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (239.67 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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