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(-)-Huperzine A
🥰Excellent
Catalog No. T3026Cas No. 102518-79-6
Alias Huperzine A, HupA
(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
(-)-Huperzine A
🥰Excellent
Purity: 99.87%
Catalog No. T3026Alias Huperzine A, HupACas No. 102518-79-6
(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $43 | In Stock | |
| 25 mg | $82 | In Stock | |
| 50 mg | $148 | In Stock | |
| 100 mg | $263 | In Stock | |
| 200 mg | $490 | In Stock | |
| 500 mg | $785 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | (-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). |
| Targets&IC50 | AChE (G4 form):7 nM(Ki) |
| In vitro | In both animal models and patients with Alzheimer's Disease (AD), (-)-Huperzine A has been shown to improve learning and memory impairments. Compared to the control group treated with saline, significant inhibition of acetylcholinesterase (AchE) activity was observed in the cortex, striatum, hippocampus, medulla, septal nuclei, cerebellum, and thalamus of rats 30 minutes post-mortem. |
| In vivo | Compared to tacrine, strychnine, galantamine, and carbachol, (-)-Huperzine A exhibits stronger inhibition of acetylcholinesterase (AChE) activity but has the least effect on butyrylcholinesterase (BuChE). (-)-Huperzine A protects cells against glutamate, hydrogen peroxide, β-amyloid, ischemia, and astrosporine-induced cytotoxicity and apoptosis. This protective function is achieved through a series of processes including the regulation of apoptotic protein expression (such as Bcl-2, Bax, p53, and caspase-3), alleviation of oxidative stress, mitochondrial protection, upregulation of nerve growth factor and its receptors, and interference with amyloid precursor protein metabolism. Notably, (-)-Huperzine A preferentially inhibits the tetrameric form of AChE (G4 form). |
| Alias | Huperzine A, HupA |
| Molecular Weight | 242.32 |
| Formula | C15H18N2O |
| Cas No. | 102518-79-6 |
| Smiles | [H][C@@]12Cc3[nH]c(=O)ccc3[C@@](N)(CC(C)=C1)C2=CC |
| Relative Density. | 1.20 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (123.8 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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