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1,4-DPCA

Catalog No. T21653   CAS 331830-20-7

1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).

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1,4-DPCA Chemical Structure
1,4-DPCA, CAS 331830-20-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 47.00
10 mg In stock $ 76.00
25 mg In stock $ 155.00
50 mg In stock $ 247.00
100 mg In stock $ 396.00
200 mg In stock $ 583.00
500 mg In stock $ 929.00
1 mL * 10 mM (in DMSO) In stock $ 52.00
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Purity: 97.75%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
In vitro 1,4-DPCA significantly reduces the colony sizes and invasive branches of T4-2 (10 μM) and ZR-75-1 cells (20 μM). 1,4-DPCA inhibits the proliferation in T4-2, ZR-75-1, MDA-MB-231 cells, and MDA-MB-157[1]. In mouse B6 cells, 1,4-DPCA specifically increases the expression of proangiogenic target genes including Hmox1 and Vegfa, and proglycolytic targets including Ldh-a, Pdk1, Glut1, and Pgk1[2].
In vivo In mice, 1,4-DPCA effectively inhibits collagen deposition within and on the outer surface of the disc, and limits connective tissue ingrowth. 1,4-DPCA suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) discs implanted in the peritoneal cavity[3].
Molecular Weight 240.21
Formula C13H8N2O3
CAS No. 331830-20-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (49.96 mM), sonification is recommended.

TargetMolReferences and Literature

1. Gaofeng Xiong, et al. Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition. BMC Cancer. 2014 Jan 2;14:1. 2. Yong Zhang, et al. Drug-induced regeneration in adult mice. Sci Transl Med. 2015 Jun 3;7(290):290ra92. 3. Ryan J Love, et al. Transient inhibition of connective tissue infiltration and collagen deposition into porous poly(lactic-co-glycolic acid) discs. J Biomed Mater Res A. 2013 Dec;101(12):3599-606.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library Glycolysis Compound Library Bioactive Compounds Library Max Transcription Factor-Targeted Compound Library Bioactive Compound Library Anti-Cancer Metabolism Compound Library Epigenetics Compound Library Inhibitor Library

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Keywords

1,4-DPCA 331830-20-7 Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase HIF-PH HIF-1α HIFs FIH P4HA1 P4HA2 1,4DPCA healing Inhibitor Hypoxia-inducible factors 1,4 DPCA wound inhibit P4HA3 inhibitor

 

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