Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 76.00 | |
25 mg | In stock | $ 155.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 396.00 | |
200 mg | In stock | $ 583.00 | |
500 mg | In stock | $ 929.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | 1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH). |
In vitro | 1,4-DPCA significantly reduces the colony sizes and invasive branches of T4-2 (10 μM) and ZR-75-1 cells (20 μM). 1,4-DPCA inhibits the proliferation in T4-2, ZR-75-1, MDA-MB-231 cells, and MDA-MB-157[1]. In mouse B6 cells, 1,4-DPCA specifically increases the expression of proangiogenic target genes including Hmox1 and Vegfa, and proglycolytic targets including Ldh-a, Pdk1, Glut1, and Pgk1[2]. |
In vivo | In mice, 1,4-DPCA effectively inhibits collagen deposition within and on the outer surface of the disc, and limits connective tissue ingrowth. 1,4-DPCA suppresses connective tissue ingrowth in porous porous poly (lactic-co-glycolic acid) discs implanted in the peritoneal cavity[3]. |
Molecular Weight | 240.21 |
Formula | C13H8N2O3 |
CAS No. | 331830-20-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (49.96 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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1,4-DPCA 331830-20-7 Chromatin/Epigenetic Metabolism HIF/HIF Prolyl-Hydroxylase HIF-PH HIF-1α HIFs FIH P4HA1 P4HA2 1,4DPCA healing Inhibitor Hypoxia-inducible factors 1,4 DPCA wound inhibit P4HA3 inhibitor