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Minesapride

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Purity:99.35%

ee:100%

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COA CSFC HNMR HPLC LCMS

Minesapride

Catalog No. T28043LCas No. 1184662-54-1

Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation.

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Pack Size	Price	Availability
1 mg	$195	In Stock
5 mg	$430	In Stock
10 mg	$636	In Stock
25 mg	$987	In Stock
50 mg	$1,360	In Stock
100 mg	$1,830	In Stock
500 mg	$3,680	In Stock
1 mL x 10 mM (in DMSO)	$497	In Stock

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Product Introduction

Bioactivity

Description	Minesapride, a novel 5-hydroxytryptamine 4 (5-HT4) receptor partial agonist, is a potential gastrointestinal prokinetic agent for the treatment of irritable bowel syndrome with constipation.
In vivo	Minesapride (1, 4, 12, or 40 mg; once daily; 4 weeks) improved in Minesapride 40 mg group abdominal symptoms score at week 4. In a phase 2 trial of patients with IBS-C in Japan, minesapride increased stool frequency (measured by CSBMs), reduced abdominal and overall IBS-C symptoms, and was well tolerated.[1]

Chemical Properties

Molecular Weight	454.95
Formula	C21H31ClN4O5
Cas No.	1184662-54-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (66.15 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1980 mL	10.9902 mL	21.9804 mL	109.9022 mL
5 mM	0.4396 mL	2.1980 mL	4.3961 mL	21.9804 mL
10 mM	0.2198 mL	1.0990 mL	2.1980 mL	10.9902 mL
20 mM	0.1099 mL	0.5495 mL	1.0990 mL	5.4951 mL
50 mM	0.0440 mL	0.2198 mL	0.4396 mL	2.1980 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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