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2',5'-Dideoxyadenosine

Catalog No. T10066 CAS 6698-26-6

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).

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2',5'-Dideoxyadenosine Chemical Structure

2',5'-Dideoxyadenosine, CAS 6698-26-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
5 mg	In stock	$ 76.00
10 mg	In stock	$ 122.00
25 mg	In stock	$ 222.00
50 mg	In stock	$ 372.00
100 mg	In stock	$ 592.00
500 mg	In stock	$ 1,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 98.66%

Biological Description

Chemical Properties

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Description	2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM).
Targets&IC50	Adenylyl cyclase:3 µM
In vitro	2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively [2]. 2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). 2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448 [3].
In vivo	2',5'-Dideoxyadenosine (0.1 mg/kg; i.p.; 15 min pre-treated) fully inhibits the natriuretic, diuretic and K+ and Cl- sparing effect of Fr?EtOAc in rats [4].
Cell Research	Primary hippocampal neurons. Concentration: 10 μM. Incubation Time: 30 min [3]
Animal Research	Male Wistar rats (3-4 months old).Dosage: 0.1 mg/kg.Administration: i.p.; 15 min pre-treated [3]

Molecular Weight	235.24
Formula	C10H13N5O2
CAS No.	6698-26-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.35 mg/mL (10 mM)

References and Literature

1. Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38(6):848-53. 2. Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25(3):331-8. 3. Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33(5):6622-6631. 4. Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae). J Ethnopharmacol. 2013 Oct 28;150(1):154-61.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Human Metabolite Library Neuronal Signaling Compound Library

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Keywords

2',5'-Dideoxyadenosine 6698-26-6 GPCR/G Protein Neuroscience Adenylyl cyclase AChR Adrenergic Receptor P-site 2',5'Dideoxyadenosine cyclase Beta Receptor analog heart adenylyl antiadrenergic Inhibitor Adenylate Cyclase inhibit nucleoside 2',5' Dideoxyadenosine inhibitor

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