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Angiogenesis HER AG-1478

AG-1478

Catalog No. T2047   CAS 153436-53-4
Synonyms: AG1478, AG 1478, NSC 693255, Tyrphostin AG-1478
Purity 99.71% Datasheet MSDS

AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.

AG-1478, CAS 153436-53-4
Pack Size Availability Price/USD Quantity
5 mg In stock 50.00
10 mg In stock 68.00
25 mg In stock 127.00
50 mg In stock 230.00
100 mg In stock 320.00
200 mg In stock 416.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Preparing Solutions
Description AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.
Targets&IC50 EGFR :ic50 3nM,   HER2 :ic50 >100μM,   PDGFR :ic50 >100μM,  
Cell Research
Cells are exposed to different concentrations of AG-1478 for 72 hours in 96-well plates. The effects of AG-1478 on cell growth are examined using an Alamar Blue assay. A 20-μL aliquot of Alamar Blue is added to each well, and its absorbance is determined using a Spectromax Scanning Micro plate Reader. The effects of AG-1478 are expressed as percentage of growth inhibition using untreated cells as the control (0% inhibition). Cellular DNA synthesis is determined using a [3H]thymidine incorporation assay. (Only for Reference)
Cell lines: U87MG
Animal Research
Animal Model: FeBALB/c nu/nu mice inoculated s.c. with A431 or U87MG.Δ2-7 tumor cells
Synonyms AG1478, AG 1478, NSC 693255, Tyrphostin AG-1478
Purity 99.71%
Appearance solid
Molecular Weight 315.75
Formula C16H14ClN3O2
CAS No. 153436-53-4

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 24 mg/mL (76 mM)

Ethanol: 11 mg/mL (34.8 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

15% Captisol: 30 mg/mL

Citations

References and Literature
1. Levitzki A, et al. Science, 1995, 267(5205), 1782-1788. 2. Han Y, et al. Cancer Res, 1996, 56(17), 3859-3861. 3. Eguchi S, et al. J Biol Chem, 1998, 273(15), 8890-8896. 4. Johns TG, et al. Proc Natl Acad Sci U S A, 2003, 100(26), 15871-15876. 5. Lee FT, et al. Clin Cancer Res, 2005, 11(19 Pt 2), 7080s-7086s. 6. Ellis AG, et al. Biochem Pharmacol, 2006, 71(10), 1422-1434. 6. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. 7. Shi Z, et al. Biochem Pharmacol, 2009, 77(5), 781-793. 7. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. 8. Shi Z, et al. Oncol Rep, 2009, 21(2), 483-489. 9. Takai N, et al. Mol Med Report, 2010, 3(3), 479-484.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Anti-infection Compound Library Tyrosine kinase inhibitor library Anti-virus Compound Library Cytokine Inhibitor Library Kinase Inhibitor Library Anti-cancer Clinical Compound Library Angiogenesis related Compound Library Preclinical Compound Library JAK STAT Compound Library

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Afatinib Dimaleate AG-1478 Afatinib Neratinib Neratinib Irbinitinib BMS 599626 Poziotinib

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