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AZD7507

Catalog No. T14380   CAS 1041852-85-0

AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.

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AZD7507 Chemical Structure
AZD7507, CAS 1041852-85-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 84.00
5 mg In stock $ 197.00
10 mg In stock $ 289.00
25 mg In stock $ 537.00
50 mg In stock $ 775.00
100 mg In stock $ 1,080.00
500 mg In stock $ 2,170.00
1 mL * 10 mM (in DMSO) In stock $ 226.00
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Purity: 99.09%
Purity: 98.01%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.
Targets&IC50 CSF-1R:32 nM, hERG:>30 μM, NaV1.5:26 μM
In vitro AZD7507 inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1. It shows inhibitory activity against hERG and NaV1.5, with IC50s of >30 and 26 μM[1].
In vivo Xenografted mice were given liposomal clodronate (Lipclod) to selectively deplete phagocytic macrophages; AZD7507 to inhibit the activation of CSF receptor 1 (CSFR1), thereby preventing monocyte differentiation into macrophages; or appropriate vehicle alone[2]. In Lipclod-, GW2580-, and AZD7507-treated mice, we observed a significant decrease the number of CD68+ macrophages in the xenografted. Mice with CC-LP-1 and SNU-1079, but not WITT-1, xenografts demonstrated both reduced tumor volume and mass after treatment with Lipclod, GW2580, and AZD7507. Furthermore, of the 8 SNU-1079 xenografts that were palpable at 3 weeks, only 4 from the GW2580 group and 6 from the AZD7507 group were large enough to recover at week 6, as they were no longer palpable and too small to detect. In the CC-LP-1 group, only 3 of the 8 tumors were detectable at 6 weeks. (In the WITT-1 line, 7 xenografts were recovered from the GW2580 and 8 from the AZD7507 group.) Depletion of macrophages using Lipclod, GW2580, or AZD7507 in all 3 xenografted lines resulted in a reduction in murine Wnt7b expression at the mRNA level[2].
Molecular Weight 454.5
Formula C23H27FN6O3
CAS No. 1041852-85-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (220.02 mM), sonification is recommended.

TargetMolReferences and Literature

1. Scott DA, et al. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. 2. Boulter L, et al. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Send to J Clin Invest. 2015 Mar 2;125(3):1269-85. 3. Candido JB, et al. CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype. Cell Rep. 2018 May 1;23(5):1448-1460.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Inhibitor Library Ion Channel Inhibitor Library Anti-Liver Cancer Compound Library Bioactive Compound Library Orally Active Compound Library Reprogramming Compound Library Anti-Prostate Cancer Compound Library

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Keywords

AZD7507 1041852-85-0 Angiogenesis JAK/STAT signaling Membrane transporter/Ion channel Tyrosine Kinase/Adaptors CSF-1R HER Sodium Channel Inhibitor CSF1R CSF-1 receptor AZD 7507 AZD-7507 c-Fms inhibit colony stimulating factor 1 receptor inhibitor

 

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