Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 84.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 537.00 | |
50 mg | In stock | $ 775.00 | |
100 mg | In stock | $ 1,080.00 | |
500 mg | In stock | $ 2,170.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 226.00 |
Description | AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity. |
Targets&IC50 | CSF-1R:32 nM, hERG:>30 μM, NaV1.5:26 μM |
In vitro | AZD7507 inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1. It shows inhibitory activity against hERG and NaV1.5, with IC50s of >30 and 26 μM[1]. |
In vivo | Xenografted mice were given liposomal clodronate (Lipclod) to selectively deplete phagocytic macrophages; AZD7507 to inhibit the activation of CSF receptor 1 (CSFR1), thereby preventing monocyte differentiation into macrophages; or appropriate vehicle alone[2]. In Lipclod-, GW2580-, and AZD7507-treated mice, we observed a significant decrease the number of CD68+ macrophages in the xenografted. Mice with CC-LP-1 and SNU-1079, but not WITT-1, xenografts demonstrated both reduced tumor volume and mass after treatment with Lipclod, GW2580, and AZD7507. Furthermore, of the 8 SNU-1079 xenografts that were palpable at 3 weeks, only 4 from the GW2580 group and 6 from the AZD7507 group were large enough to recover at week 6, as they were no longer palpable and too small to detect. In the CC-LP-1 group, only 3 of the 8 tumors were detectable at 6 weeks. (In the WITT-1 line, 7 xenografts were recovered from the GW2580 and 8 from the AZD7507 group.) Depletion of macrophages using Lipclod, GW2580, or AZD7507 in all 3 xenografted lines resulted in a reduction in murine Wnt7b expression at the mRNA level[2]. |
Molecular Weight | 454.5 |
Formula | C23H27FN6O3 |
CAS No. | 1041852-85-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (220.02 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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AZD7507 1041852-85-0 Angiogenesis JAK/STAT signaling Membrane transporter/Ion channel Tyrosine Kinase/Adaptors CSF-1R HER Sodium Channel Inhibitor CSF1R CSF-1 receptor AZD 7507 AZD-7507 c-Fms inhibit colony stimulating factor 1 receptor inhibitor