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Alvelestat

Catalog No. T3107 CAS 848141-11-7

Synonyms: AZD9668, Avelestat

Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.

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Alvelestat, CAS 848141-11-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 38.00
5 mg	In stock	$ 54.00
10 mg	In stock	$ 81.00
25 mg	In stock	$ 159.00
50 mg	In stock	$ 243.00
100 mg	In stock	$ 387.00
500 mg	In stock	$ 923.00
1 mL * 10 mM (in DMSO)	In stock	$ 72.00

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Purity: 99.87%

Purity: 99.26%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Alvelestat (AZD9668) is an orally bioavailable, selective and reversible inhibitor of human neutrophil elastase (NE), with potential anti-inflammatory activity.
Targets&IC50	Neutrophil elastase:12 nM, Neutrophil elastase:9.4 nM(Ki)
In vitro	In a mouse model of (smoke)-induced airway inflammation, AZD9668 significantly reduced the number of (neutrophils) in the bronchoalveolar lavage (BAL) and the level of BAL IL-1β. Oral administration of AZD9668 in both mice and rats was able to inhibit (NE)-induced lung injury.
In vivo	In whole blood stimulated by yeast polysaccharide, AZD9668 effectively inhibits NE (NE) activity in the supernatant of antigen-challenged cells and on the surface of stimulated polymorphonuclear cells.

Synonyms	AZD9668, Avelestat
Molecular Weight	545.53
Formula	C25H22F3N5O4S
CAS No.	848141-11-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 33 mg/mL(60.5 mM)

References and Literature

1. Stevens T, et al. J Pharmacol Exp Ther. 2011, 339(1), 313-320.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Drug Repurposing Compound Library ReFRAME Related Library Immunology/Inflammation Compound Library Human Metabolite Library Clinical Compound Library Bioactive Compound Library Anti-Aging Compound Library Fluorochemical Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Alvelestat 848141-11-7 Others Proteases/Proteasome Serine Protease Elastase AZD9668 AZD 9668 Inhibitor AZD-9668 Avelestat inhibit inhibitor

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