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BGT226

Catalog No. T6072LCas No. 915020-55-2
Alias NVP-BGT226, BGT226 free base

BGT226 (NVP-BGT226) is a novel dual PI3K/mTOR inhibitor, targeting PI3K α, β, and γ with IC50 values of 4 nM, 63 nM, and 38 nM, respectively.

BGT226

BGT226

Purity: 100%
Catalog No. T6072LAlias NVP-BGT226, BGT226 free baseCas No. 915020-55-2
BGT226 (NVP-BGT226) is a novel dual PI3K/mTOR inhibitor, targeting PI3K α, β, and γ with IC50 values of 4 nM, 63 nM, and 38 nM, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$116In Stock
10 mg$197In Stock
25 mg$433In Stock
50 mg$638In Stock
100 mg$892In Stock
1 mL x 10 mM (in DMSO)$158In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
BGT226 (NVP-BGT226) is a novel dual PI3K/mTOR inhibitor, targeting PI3K α, β, and γ with IC50 values of 4 nM, 63 nM, and 38 nM, respectively.
Targets&IC50
PI3Kγ:38 nM, PI3Kβ:63 nM, PI3Kα:4 nM
In vitro
Growth inhibition experiment showed that BGT226 had antitumor activity. BGT226 significantly inhibited cell growth with IC50 < 20 nM. BGT226 also induced cancer cell apoptosis at nanomolar concentration, IC50 ≤ 25 nM[1][2][3].
In vivo
BGT226 significantly delayed tumor growth on the transplanted tumor animal model. This effect was dose-dependent, accompanied by inhibition of p-p70 S6 kinase cytoplasmic expression and autophagy body formation[2].
AliasNVP-BGT226, BGT226 free base
Chemical Properties
Molecular Weight534.53
FormulaC28H25F3N6O2
Cas No.915020-55-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/ml (121.6 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8708 mL9.3540 mL18.7080 mL93.5401 mL
5 mM0.3742 mL1.8708 mL3.7416 mL18.7080 mL
10 mM0.1871 mL0.9354 mL1.8708 mL9.3540 mL
20 mM0.0935 mL0.4677 mL0.9354 mL4.6770 mL
50 mM0.0374 mL0.1871 mL0.3742 mL1.8708 mL
100 mM0.0187 mL0.0935 mL0.1871 mL0.9354 mL

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