Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bemesetron (MDL 72222) is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 50.00 | |
25 mg | In stock | $ 64.00 | |
50 mg | In stock | $ 86.00 |
Description | Bemesetron (MDL 72222) is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects. |
Targets&IC50 | 5-HT3 receptor:0.33 nM |
In vitro | In primary cortical neuronal cells, Bemesetron (1 μM) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity. Bemesetron (0.01, 0.1 and 1 μM) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease showing inhibition of 74.9 and 79.0% with 1 μM and 5 μM, respectively[2]. |
In vivo | In male adult albino mice, Bemesetron (1 mg/kg; i.p.) causes a significant reduction of catalepsy, while Bemesetron (10 mg/kg; i.p.) significantly potentiates the phenomenon. The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol[3]. |
Synonyms | TROPANYL 3,5-DICHLOROBENZOATE, 3-TROPANYL-3,5-DICHLOROBENZOATE, MDL 72222 |
Molecular Weight | 314.21 |
Formula | C15H17Cl2NO2 |
CAS No. | 40796-97-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (6.37 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Bemesetron 40796-97-2 GPCR/G Protein Neuroscience 5-HT Receptor TROPANYL 3,5-DICHLOROBENZOATE MDL-72222 3-TROPANYL-3,5-DICHLOROBENZOATE MDL 72222 MDL72222 inhibitor inhibit