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Bobcat339

Catalog No. T5198 CAS 2280037-51-4

Synonyms: Bobcat339 hydrochloride

Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bobcat339, CAS 2280037-51-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 76.00
25 mg	In stock	$ 163.00
50 mg	In stock	$ 263.00
100 mg	In stock	$ 388.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
Targets&IC50	TET2:73 μM (cell free), TET1:33 μM (cell free)
In vitro	HT-22 cells were treated with 10 μM Bobcat339 in 1% DMSO for 24 hrs and lysed. Cells treated with Bobcat339 had significantly reduced global 5hmC levels as compared to vehicle control.

Synonyms	Bobcat339 hydrochloride
Molecular Weight	297.74
Formula	C16H12ClN3O
CAS No.	2280037-51-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (151.14 mM), Sonication is recommended.

References and Literature

1. Chua GNL, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185. 2. Xu X, Yuan X, Ni J, et al. MAGI2‐AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2[J]. Journal of Cellular Physiology. 2021, 236(2): 1116-1130.

Citations

1. Shi Q, Liu R, Chen L. Ferroptosis inhibitor ferrostatin-1 alleviates homocysteine-induced ovarian granulosa cell injury by regulating TET activity and DNA methylation. Molecular Medicine Reports. 2022, 25(4): 1-9 2. Xu X, Yuan X, Ni J, et al. MAGI2‐AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2. Journal of Cellular Physiology. 2021, 236(2): 1116-1130 3. Shi Q, Liu R, Chen L. Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation. Molecular Medicine Reports. 2022, 25(4): 1-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Aging Compound Library Chromatin Modification Compound Library Bioactive Compound Library NO PAINS Compound Library Epigenetics Compound Library Stem Cell Differentiation Compound Library Methylation Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bobcat339 2280037-51-4 Chromatin/Epigenetic DNA Methyltransferase Cytosine-based,TET Bobcat339 Hydrochloride epigenetics enzyme Bobcat-339 TET1,TET2 Inhibitor Bobcat 339 Bobcat339 hydrochloride DNA MTases DNMTs inhibit inhibitor

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