Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50<20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 146.00 | |
2 mg | In stock | $ 198.00 | |
5 mg | In stock | $ 308.00 | |
10 mg | In stock | $ 443.00 | |
25 mg | In stock | $ 732.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,390.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 323.00 |
Description | CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin. |
Targets&IC50 | CDK6:37.68 nM, CDK2:3.27 nM, CDK9:5.78 nM, CDK4:8.18 nM, CDK7:134.26 nM, CDK1:8.17 nM |
In vitro | CDKI-73, one of the most potent CDK9 inhibitors, against a panel of AML cell lines and samples derived from 97 patients.?CDKI-73 induced cancer cells undergoing apoptosis through transcriptional downregulation of anti-apoptotic proteins Bcl-2, Mcl-1 and XIAP by majorly targeting CDK9[3]. |
In vivo | CDKI-73 exhibited a favorable pharmacokinetic profile with oral bioavailability of F = 56% following a single intravenous bolus dose at 2 mg/kg and an oral dose at 10 mg/kg in mice [1]. |
Molecular Weight | 394.45 |
Formula | C15H15FN6O2S2 |
CAS No. | 1421693-22-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 52 mg/mL (131.83 mM)
You can also refer to dose conversion for different animals. More
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CDKI-73 1421693-22-2 Apoptosis Cell Cycle/Checkpoint CDK toxicity Inhibitor low AML Acute LS 007 myeloid LS007 leukemia CLL LS-007 endosome Cyclin dependent kinase CDKI 73 CDKI73 inhibit inhibitor