Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 243.00 | |
50 mg | In stock | $ 449.00 | |
100 mg | In stock | $ 659.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 85.00 |
Description | Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels. |
In vitro | Cabergoline(10 μM) is used to investigate its neuroprotective effects. MAP2 staining reveals that Cabergoline significantly suppresses the loss of neurons caused by H2O2 incubation. Pretreatment with Cabergoline inhibits H2O2-induced neuronal cell death in a dose-dependent manner. Cabergoline prevents apoptotic cell death following H2O2 exposure [1]. |
In vivo | Cabergoline demonstrates a longer elimination half-life (63 to 109 hours) compared to other D2-like receptor agonists, offering prolonged clinical benefits from a single dose and potential enhancements in the quality of life for individuals with chronic conditions [1]. It notably reduces the number of rapid eye movement (REM) sleep bouts in female mice, achieving a 67.3% reduction (F(1,11)=12.892, P=0.004) in non-restrained subjects, with the most considerable decrease observed during the dark phase (82.3% reduction). In male mice, Cabergoline significantly lowers baseline Prolactin (PRL) levels by 98.5% (F(1,6)=13.192, P=0.011) to 0.08 ng/mL within two hours post-injection. PRL levels normalize to baseline (5.0±0.60 ng/mL; F(1,6)=0.715, P=0.43) following a seven-day recovery period [2]. |
Synonyms | FCE-21336 |
Molecular Weight | 451.6 |
Formula | C26H37N5O2 |
CAS No. | 81409-90-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL(70.86 mM)
You can also refer to dose conversion for different animals. More
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Cabergoline 81409-90-7 Autophagy GPCR/G Protein Neuroscience 5-HT Receptor Dopamine Receptor FCE-21336 FCE 21336 FCE21336 inhibit Inhibitor inhibitor