Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 45.00 | |
1 g | In stock | $ 53.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol. |
In vitro | Intradermal injection of Clotrimazole in mice stimulates capsaicin-sensitive and mustard oil-sensitive trigeminal neurons, inducing nocifensive behavior and thermal hyperalgesia. In TRPV1 knockout mice, Clotrimazole-induced pain behavior is inhibited by the TRPV1 antagonist BCTC [1,2,3,4-tetrahydro-6-trichloromethyl-pyrimidine-2-one]. |
In vivo | In the CRI-G1 whole-cell of a rat insulinoma cell line, Clotrimazole antagonizes ADP-ribose-activated and single-channel currents. Clotrimazole effectively and rapidly inhibits parasite growth across five different strains of the malignant malaria protozoan. In HEK-293 cells expressing recombinant human TRPM2, Clotrimazole inhibits ADP-ribose-activated currents. At 2 mM concentration, Clotrimazole completely suppresses parasite replication, resulting in the destruction of host cells. Furthermore, Clotrimazole at concentrations ranging from 3 mM to 30 mM entirely inhibits TRPM2-mediated currents. |
Synonyms | BAY b 5097, FB 5097 |
Molecular Weight | 344.84 |
Formula | C22H17ClN2 |
CAS No. | 23593-75-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (26.1 mM)
Ethanol: 64 mg/mL (185.6 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Clotrimazole 23593-75-1 Autophagy Microbiology/Virology Antibacterial Antibiotic Antifungal Antifection Inhibitor FB-5097 inhibit FB5097 BAY b 5097 Fungal FB 5097 Bacterial inhibitor