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DM4

Catalog No. T15141 CAS 796073-69-3

Synonyms: Ravtansine

DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DM4, CAS 796073-69-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 255.00
50 mg	In stock	$ 448.00
1 mL * 10 mM (in DMSO)	In stock	$ 115.00

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Purity: 98.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
In vitro	DM4 is a cytotoxic maytansinoid drug and it is a structural analogue of maytansine. It also is a new thiol-containing and potent maytansinoid. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Which enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].

Synonyms	Ravtansine
Molecular Weight	780.37
Formula	C38H54ClN3O10S
CAS No.	796073-69-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 99 mg/mL (126.86 mM), Sonication is recommended.

References and Literature

1. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Microtubule-Targeted Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Anti-Colorectal Cancer Compound Library Covalent Inhibitor Library Anti-Pancreatic Cancer Compound Library Anti-Lung Cancer Compound Library

Related Products

Related compounds with same targets

2-Methoxyestradiol PE859 10-Deacetyltaxol VCMMAE N-Phenylbenzylamine MT189 Tasidotin hydrochloride BTB-1

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DM4 796073-69-3 Cytoskeletal Signaling Others Microtubule Associated Ravtansine Microtubule/Tubulin Inhibitor inhibit ADC Payload ADC Cytotoxin DM 4 DM-4 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.