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DMH-1

Catalog No. T1942   CAS 1206711-16-1
Synonyms: DMH1

DMH-1 is a potent and selective BMP inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
DMH-1 Chemical Structure
DMH-1, CAS 1206711-16-1
Pack Size Availability Price/USD Quantity
5 mg In stock $ 53.00
10 mg In stock $ 84.00
25 mg In stock $ 163.00
50 mg In stock $ 291.00
100 mg In stock $ 455.00
500 mg In stock $ 987.00
1 mL * 10 mM (in DMSO) In stock $ 63.00
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Purity: 99.92%
Purity: 99.7%
Purity: 99.57%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description DMH-1 is a potent and selective BMP inhibitor.
Targets&IC50 ALK2:107.9 nM
Kinase Assay Kinase assay: All kinase assays are conducted by Reaction Biology Corp. In brief, compounds are tested at 10 concentrations by 3-fold serial dilutions starting at 30 μM, using nonspecific kinase inhibitor staurosporine as control. In vitro kinase reactions are carried out in the presence of 10 μM (33P)γATP. Five kinases tested are the human BMP type-I receptor activin receptor-like kinase 2 (ALK-2/ACVR1), the human TGFβ type-I receptor activin receptor-like kinase 5 (Alk5/TGFβR1), the human VEGF type-II receptor (KDR/Flk-1/VEGFR2), the human AMP-activated protein kinase (AMPK/A1/B1/G1) and the human platelet-derived growth factor receptor-β (PDGFRβ).
Cell Research About 10,000 A549 cells per well are seeded in 96-well plates and incubated for overnight. The culture medium is then changed to fresh medium containing DMSO or DMH1 at various concentrations. The cells are then incubated for 48 hours and 96 hours before treatment termination by replacing the medium with 100 μL of 10% trichloroacetic acid in 1× PBS, followed by incubation at 4°C for at least 1 hour. Subsequently, the plates are washed with water and air dried. The plates are stained with 50 μL 0.4% sulphorhodamine assay in 1% acetic acid for 30 minutes at room temperature. Unbound dye is washed off with 1% acetic acid. After air drying and solubilization of the protein-bound dye in 10 mM Tris solution, absorbance is read in a microplate reader at 565 nm.(Only for Reference)
Synonyms DMH1
Molecular Weight 380.44
Formula C24H20N4O
CAS No. 1206711-16-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.5 mg/mL (32.86 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Hao J, et al. ACS Chem Biol. 2010, 5(2), 245-253. 2. Cross EE, et al. ACS Chem Biol. 2011, 6(9), 952-961. 3. Ao A, et al. PLoS One. 2012, 7(7), e41627. 4. Hao J, et al. PLoS One. 2014, 9(3), e90748. 6. Hover LD, et al. Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. Cancer Lett. 2015 Nov 1;368(1):79-87. 7. Eixarch H, Calvo-Barreiro L, Costa C, et al. Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis[J]. Neurotherapeutics. 2020: 1-16.

TargetMolCitations

1. Jiang M, Xiao Y, Weigao E, et al. Characterization of the Zebrafish Cell Landscape at Single-Cell Resolution. Frontiers in Cell and Developmental Biology. 2021, 9. 2. Eixarch H, Calvo-Barreiro L, Costa C, et al. Inhibition of the BMP Signaling Pathway Ameliorated Established Clinical Symptoms of Experimental Autoimmune Encephalomyelitis. Neurotherapeutics. 2020: 1-16. 3. Gao L T, Yuan J Q, Zhang Z Y, et al.Hypermethylation of the Bmp4 promoter dampens binding of HIF-1α and impairs its cardiac protective effects from oxidative stress in prenatally GC-exposed offspring.Cellular and Molecular Life Sciences.2023, 80(3): 58.

Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library TGF-beta/Smad Compound Library Tyrosine Kinase Inhibitor Library Anti-Fibrosis Compound Library Anti-Aging Compound Library Reprogramming Compound Library Anti-Breast Cancer Compound Library Cytokine Inhibitor Library Anti-Lung Cancer Compound Library Anti-Cancer Compound Library

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Keywords

DMH-1 1206711-16-1 Angiogenesis Autophagy Stem Cells Tyrosine Kinase/Adaptors TGF-beta/Smad ALK Inhibitor Transforming growth factor beta receptors DMH 1 inhibit TGF-β Receptor DMH1 inhibitor

 

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