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Dexamethasone

Catalog No. T1076 CAS 50-02-2

Synonyms: Dexamethasone (DHAP), Prednisolone F, Hexadecadrol, MK 125, NSC 34521

Purity 99.91% Datasheet MSDS

Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses

Dexamethasone, CAS 50-02-2

Pack Size	Availability	Price/USD
10 mg	In stock	15.00
25 mg	In stock	20.00
50 mg	In stock	28.00
100 mg	In stock	35.00
200 mg	In stock	42.00
500 mg	In stock	50.00
1 g	In stock	86.00
1 mL * 10 mM (in DMSO)	In stock	54.00

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Purity 98.00%

HNMR COA Datasheet MSDS

Purity 99.90%

HNMR HPLC COA Datasheet MSDS

Purity 99.91%

HNMR HPLC COA Datasheet MSDS

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Description	Dexamethasone is a glucocorticoid receptor agonist and an IL receptor modulator.Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses
Targets&IC50	Annexin A1, Glucocorticoid Receptor, IL receptor, iNOS, MRP1, NR,
In vitro	GM-CSF release from A549 cells was inhibited by dexamethasone (EC50 = 2.2 nM). The concentration-dependent ability of dexamethasone (EC50 = 36 nM) to induce transcription of the beta2-receptor was found to correlate with GR DNA binding and occurred at 10-100 fold higher concentrations than the inhibition of GM-CSF release [1]. Following treatment with 1 microM dexamethasone, there was a decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein, and dextrans of up to 20 KDa [2].
In vivo	Kd values (mean+/-SE) for cortisol in human mononuclear leukocytes (HML) of hypertensive patients were higher than in control subjects (24.6 versus 17.5 nmol/L). Binding capacity (4978 versus 4131 sites/cell), Kd values for dexamethasone (6.7 versus 5.7 nmol/L), and IC50 values for dexamethasone (3.4 versus 3.1 nmol/L) and cortisol (12.2 versus 9.5 nmol/L) were not significantly different [3]. Powerful reduction of neutrophils in bronchoalveolar lavage fluid (BALF) was obtained by a single i.p. injection of dexamethasone (10 mg/kg), whereas treatment with N-acetylcysteine (NAC) only resulted in reduction of neutrophils when administered at a high dose (500 mg/kg). A significant decrease of tumour necrosis factor-alpha, IL-1alpha, IL-1beta IL-6, IL- 12p40, and MIP-1alpha mRNA when mice where treated with dexamethasone but not when treated with NAC [4].
Animal Research	NAC was administered at three different doses (10, 100 and 500 mg/kg body weight). At the highest concentration, the acidic pH of the NAC solution was adjusted by adding NaOH. Dexamethasone was administered as a single injection of 1 or 10 mg/kg. Both drugs were dissolved in saline and 400 μl were injected intraperitoneally, either 1 h before or 1 h after LPS exposure. In one experiment, NAC (100 and 500 mg/kg) was injected successively every 4·5 h, starting 1 h before challenge (five injections in total). A control group of LPS-exposed animals were injected intraperitoneally with solvent alone (saline). Intratracheal administration was performed by instillation of 100 μl NAC (50, 100 or 500 mg/kg) or dexamethasone (10 mg/kg) into the lungs of mice anaesthetized with 15 mg/kg Rapinovet (i.v.) [4]. Animal Model: C57Bl/6JBom mice

Synonyms	Dexamethasone (DHAP), Prednisolone F, Hexadecadrol, MK 125, NSC 34521
Purity	99.91%
Appearance	solid
Molecular Weight	392.46
Formula	C22H29FO5
CAS No.	50-02-2

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 73 mg/mL (186 mM)

Ethanol: 6 mg/mL (15.28 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Solution 1

30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL

Citations

References and Literature

1. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11. 1. Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11. 2. Romero IA, et al. Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells. Neurosci Lett. 2003 Jun 26;344(2):112-6. 2. Romero IA, et al. Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells. Neurosci Lett. 2003 Jun 26;344(2):112-6. 3. Mulatero P, et al. Impaired cortisol binding to glucocorticoid receptors in hypertensive patients. Hypertension. 1997 Nov;30(5):1274-8. 3. Mulatero P, et al. Impaired cortisol binding to glucocorticoid receptors in hypertensive patients. Hypertension. 1997 Nov;30(5):1274-8. 4. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56. 4. Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56.

Related Compound Libraries

This product is contained In the following compound libraries：

Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Stem cell Differentiation Compound Library Autophagy Compound Library Endocrinology-Hormones Library FDA-approved Drug Library Immunology/Inflammation Compound Library Cytokine Inhibitor Library GPCR Compound Library Fluorochemical Library Anti-Metabolism Disease Compound Library

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